R
Richard B. Kim
Researcher at University of Western Ontario
Publications - 380
Citations - 33088
Richard B. Kim is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 89, co-authored 328 publications receiving 30436 citations. Previous affiliations of Richard B. Kim include London Health Sciences Centre & St. Jude Children's Research Hospital.
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Hepatocyte nuclear factors (HNF) 4α and 1α synergistically up-regulate car-mediated transcriptional activity of human CYP2C9 gene
TL;DR: The aim of this study was to define the roles of HNF4α and HNF1α in CAR‐mediated transactivation of human CYP2C9 gene.
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Identification of nonsynonomous polymorphisms of human organic anion transporting polypeptide‐A (OATP‐A) associated with altered transport activity
TL;DR: The data suggest that OATP‐A polymorphisms may contribute to inter‐individual variability in intestinal absorption and CNS penetration of substrate drugs, and is likely due to altered intrinsic activity of the transporter.
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Neither cardiac mitochondrial DNA variation or copy number contribute to congenital heart disease risk.
Jon A. L. Willcox,Joshua T. Geiger,Sarah U. Morton,David M. McKean,Daniel Quiat,Joshua M. Gorham,Angela C. Tai,Steven R. DePalma,Daniel Bernstein,Martina Brueckner,Wendy K. Chung,Alessandro Giardini,Elizabeth Goldmuntz,Jonathan R. Kaltman,Richard B. Kim,Jane W. Newburger,Yufeng Shen,Deepak Srivastava,Martin Tristani-Firouzi,Bruce Gelb,George A. Porter,Jonathan G. Seidman,Christine E. Seidman +22 more
TL;DR: In this paper , the mtDNA sequence and copy number variation contribute to cardiac defects in congenital heart disease (CHD) and mtDNAcns were calculated and rare, non-synonymous mtDNA mutations were identified in 1,837 CHD-affected proband-parent trios, 116 CHDaffected singletons, and 114 paired cardiovascular tissue/blood samples.
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The Safety of Natalizumab in Patients with Relapsing Multiple Sclerosis: An Update from TOUCH and TYGRIS: 1018
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DPYD Exon 4 Deletion Associated with Fluoropyrimidine Toxicity and Importance of Copy Number Variation
TL;DR: In this paper , the presence of a haploid dihydropyrimidine dehydrogenase (DPYD) exon 4 deletion was found to be an underappreciated determinant of fluoropyrimidine toxicity.