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Richard E. B. Seftor
Researcher at University of Arizona
Publications - 25
Citations - 2807
Richard E. B. Seftor is an academic researcher from University of Arizona. The author has contributed to research in topics: Cell culture & Trabecular meshwork. The author has an hindex of 16, co-authored 25 publications receiving 2734 citations. Previous affiliations of Richard E. B. Seftor include University of Iowa Hospitals and Clinics & University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
Acidic pH enhances the invasive behavior of human melanoma cells.
Raul Martinez-Zaguilan,Elisabeth A. Seftor,Richard E. B. Seftor,Yi Wen Chu,Robert J. Gillies,Mary J.C. Hendrix +5 more
TL;DR: It is observed that culturing of cells at mildly acidic pH induces them to become more invasive, and cells cultured at acidic pH were more aggressive than control cells when tested at the same medium pH.
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Role of the alpha v beta 3 integrin in human melanoma cell invasion.
Richard E. B. Seftor,Elisabeth A. Seftor,Kurt R. Gehlsen,William G. Stetler-Stevenson,Peter D. Brown,Erkki Ruoslahti,Mary J.C. Hendrix +6 more
TL;DR: Analysis of type IV collagenase expression in cells treated with anti-alpha v beta 3 antibody showed higher levels of both the secreted 72-kDa enzyme and its mRNA, which could underlie the elevated expression of metalloproteinase and the enhanced invasion of A375M cells through basement membrane matrices.
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Molecular determinants of ovarian cancer plasticity.
Anil K. Sood,Elisabeth A. Seftor,Mavis S. Fletcher,Lynn M. G. Gardner,Paul M. Heidger,Richard E. Buller,Richard E. B. Seftor,Mary J.C. Hendrix +7 more
TL;DR: The data revealed that the invasive ovarian cancer cells, but not normal ovarian surface epithelial cells, formed patterned networks containing solid and hollow matrix channels when grown in three-dimensional cultures containing Matrigel or type I collagen, in the absence of endothelial cells or fibroblasts.
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A simple quantitative assay for studying the invasive potential of high and low human metastatic variants
Mary J.C. Hendrix,Mary J.C. Hendrix,Elisabeth A. Seftor,Elisabeth A. Seftor,Richard E. B. Seftor,Richard E. B. Seftor,Isaiah J. Fidler,Isaiah J. Fidler +7 more
TL;DR: This paper presents a more reliable model for studying the extent of tumor cell migration and invasion in vitro and utilization of such a reconstituted matrix for in vitro invasion studies allows one the opportunity to examine tumor cell attachment, Migration and invasion of a uniform matrix over an extended period of time.
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Characterization of a highly invasive and spontaneously metastatic human malignant melanoma cell line.
Danny R. Welch,J. E. Bisi,B. E. Miller,D. Conaway,E. A. Seftor,K. H. Yohem,L. B. Gilmore,Richard E. B. Seftor,Motowo Nakajima,Mary J.C. Hendrix +9 more
TL;DR: Because C8161 is so highly malignant, amenable to experimental manipulation, and its behavior in nude mice mimics the clinical course of malignant melanoma, this cell line will prove valuable for studying properties associated with human melanoma tumor progression.