R
Richard E. Trager
Researcher at Medical University of South Carolina
Publications - 7
Citations - 582
Richard E. Trager is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Mitochondrion & Surface plasmon resonance. The author has an hindex of 6, co-authored 6 publications receiving 536 citations. Previous affiliations of Richard E. Trager include Genomics Institute of the Novartis Research Foundation.
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Journal ArticleDOI
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen
David Plouffe,Achim Brinker,Case W. McNamara,Kerstin Henson,Nobutaka Kato,Kelli Kuhen,Advait Nagle,Francisco Adrian,Jason T. Matzen,Paul A. Anderson,Tae-gyu Nam,Nathanael S. Gray,Arnab Chatterjee,Jeff Janes,S. Frank Yan,Richard E. Trager,Jeremy S. Caldwell,Peter G. Schultz,Yingyao Zhou,Elizabeth A. Winzeler +19 more
TL;DR: An efficient and robust high-throughput cell-based screen based on proliferation of Plasmodium falciparum in erythrocytes, which identified most known antimalarials and many novel chemical scaffolds, which likely act through both known and novel pathways.
Journal ArticleDOI
The β2-Adrenoceptor Agonist Formoterol Stimulates Mitochondrial Biogenesis
Lauren P. Wills,Richard E. Trager,Gyda C. Beeson,Christopher C. Lindsey,Yuri K. Peterson,Craig Beeson,Rick G. Schnellmann +6 more
TL;DR: Cheminformatic modeling, virtual chemical library screening, and experimental validation identified nisoxetine from the Sigma Library of Pharmacologically Active Compounds and two compounds from the ChemBridge DIVERSet that increased mitochondrial respiratory capacity as compelling evidence for the use and development of β2-AR ligands for therapeutic MB.
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High-throughput respirometric assay identifies predictive toxicophore of mitochondrial injury
Lauren P. Wills,Gyda C. Beeson,Richard E. Trager,Christopher C. Lindsey,Craig Beeson,Yuri K. Peterson,Rick G. Schnellmann,Rick G. Schnellmann +7 more
TL;DR: It is hypothesized that discrete toxicophores defined by distinct chemical entities can identify previously unidentified mitochondrial toxicants and advance the prediction of mitochondrial toxicity for both drug discovery and risk assessment.
Journal ArticleDOI
β2-Adrenoceptor agonists in the regulation of mitochondrial biogenesis.
Yuri K. Peterson,Robert B. Cameron,Lauren P. Wills,Richard E. Trager,Chris C. Lindsey,Craig Beeson,Rick G. Schnellmann,Rick G. Schnellmann +7 more
TL;DR: The specificity and chemical rationale of a panel of β2-adrenoceptor agonists with regards to mitochondrial biogenesis is reported, with four unique features elucidating the spatial and chemical characteristics required to stimulate MB.
Journal ArticleDOI
Time-resolved fluorescence resonance energy transfer and surface plasmon resonance-based assays for retinoid and transthyretin binding to retinol-binding protein 4.
Orzala Sharif,Huiyong Hu,Heath E. Klock,Eric Hampton,Edward Nigoghossian,Mark W. Knuth,Jason T. Matzen,Paul Anderson,Richard E. Trager,Tetsuo Uno,Richard Glynne,Sassan M. Azarian,Jeremy S. Caldwell,Achim Brinker +13 more
TL;DR: To enable the search for nonretinoid molecules with fenretinide-like activities, a HTS-compatible homogeneous TR-FRET assay monitoring the displacement of retinoic acid derivatives from RBP4 in high-density 384-well and 1536-well microtiter plate formats was developed.