S
S. Frank Yan
Researcher at Genomics Institute of the Novartis Research Foundation
Publications - 11
Citations - 1717
S. Frank Yan is an academic researcher from Genomics Institute of the Novartis Research Foundation. The author has contributed to research in topics: Gene & PubChem. The author has an hindex of 8, co-authored 11 publications receiving 1612 citations. Previous affiliations of S. Frank Yan include Novartis.
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Journal ArticleDOI
Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle
Karine G. Le Roch,Jeffrey R. Johnson,Laurence Florens,Yingyao Zhou,Andrey Santrosyan,Munira Grainger,S. Frank Yan,Kim C. Williamson,Anthony A. Holder,Daniel J. Carucci,John R. Yates,Elizabeth A. Winzeler +11 more
TL;DR: Potentially post-transcriptionally regulated genes are identified, and families of functionally related genes were observed to share similar patterns of mRNA and protein accumulation.
Journal ArticleDOI
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen
David Plouffe,Achim Brinker,Case W. McNamara,Kerstin Henson,Nobutaka Kato,Kelli Kuhen,Advait Nagle,Francisco Adrian,Jason T. Matzen,Paul A. Anderson,Tae-gyu Nam,Nathanael S. Gray,Arnab Chatterjee,Jeff Janes,S. Frank Yan,Richard E. Trager,Jeremy S. Caldwell,Peter G. Schultz,Yingyao Zhou,Elizabeth A. Winzeler +19 more
TL;DR: An efficient and robust high-throughput cell-based screen based on proliferation of Plasmodium falciparum in erythrocytes, which identified most known antimalarials and many novel chemical scaffolds, which likely act through both known and novel pathways.
Journal ArticleDOI
A probability-based approach for the analysis of large-scale RNAi screens.
Renate König,Chih-yuan Chiang,Buu P. Tu,S. Frank Yan,Paul DeJesus,Paul DeJesus,Angelica Romero,Tobias Bergauer,Anthony P. Orth,Ute Krueger,Yingyao Zhou,Sumit K. Chanda,Sumit K. Chanda +12 more
TL;DR: This work describes a statistical analysis methodology designed to minimize the impact of off-target activities upon large-scale RNA interference screens in mammalian cells and establishes that the optimal redundancy for efficacious RNAi collections is between 4–6 siRNAs per gene.
Journal ArticleDOI
An efficient rapid system for profiling the cellular activities of molecular libraries
Jonathan S. Melnick,Jeff Janes,Sungjoon Kim,Jim Yuchen Chang,Daniel G. Sipes,Drew Gunderson,Laura Jarnes,Jason T. Matzen,Michael Garcia,Tami Hood,Ronak Beigi,Gang Xia,Richard A. Harig,Hayk Asatryan,S. Frank Yan,Yingyao Zhou,Xiang-ju Gu,Alham Saadat,Vicki Zhou,Frederick J. King,Christopher M. Shaw,Andrew I. Su,Robert T. Downs,Nathanael S. Gray,Peter G. Schultz,Markus Warmuth,Jeremy S. Caldwell +26 more
TL;DR: A robotic system, termed the automated compound profiler, capable of both propagating a large number of cell lines in parallel and assaying large collections of molecules simultaneously against a matrix of cellular assays in a highly reproducible manner is described.
Journal ArticleDOI
In silico discovery of transcription regulatory elements in Plasmodium falciparum
Jason A. Young,Jeffery R Johnson,Christopher Benner,S. Frank Yan,Kaisheng Chen,Karine G. Le Roch,Yingyao Zhou,Elizabeth A. Winzeler,Elizabeth A. Winzeler +8 more
TL;DR: The fact that regulatory elements were predicted from a diverse range of functional gene clusters supports the hypothesis that cis-regulatory elements play a role in the transcriptional control of many P. falciparum biological processes.