J
Jeff Janes
Researcher at Genomics Institute of the Novartis Research Foundation
Publications - 16
Citations - 2974
Jeff Janes is an academic researcher from Genomics Institute of the Novartis Research Foundation. The author has contributed to research in topics: Expression quantitative trait loci & Dorsal root ganglion. The author has an hindex of 11, co-authored 16 publications receiving 2736 citations. Previous affiliations of Jeff Janes include Scripps Research Institute & Novartis.
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Journal ArticleDOI
BioGPS: an extensible and customizable portal for querying and organizing gene annotation resources.
Chunlei Wu,Camilo Orozco,Jason Boyer,Marc Leglise,James Goodale,Serge Batalov,Christopher L Hodge,James Haase,Jeff Janes,Jon W. Huss,Andrew I. Su +10 more
TL;DR: BioGPS http://biogps.gnf.org is introduced, a centralized gene portal for aggregating distributed gene annotation resources, and embraces the principle of community intelligence, enabling any user to easily and directly contribute to the BioGPS platform.
Journal ArticleDOI
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen
David Plouffe,Achim Brinker,Case W. McNamara,Kerstin Henson,Nobutaka Kato,Kelli Kuhen,Advait Nagle,Francisco Adrian,Jason T. Matzen,Paul A. Anderson,Tae-gyu Nam,Nathanael S. Gray,Arnab Chatterjee,Jeff Janes,S. Frank Yan,Richard E. Trager,Jeremy S. Caldwell,Peter G. Schultz,Yingyao Zhou,Elizabeth A. Winzeler +19 more
TL;DR: An efficient and robust high-throughput cell-based screen based on proliferation of Plasmodium falciparum in erythrocytes, which identified most known antimalarials and many novel chemical scaffolds, which likely act through both known and novel pathways.
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A Genome-wide RNAi Screen for Modifiers of the Circadian Clock in Human Cells
Eric E. Zhang,Eric E. Zhang,Andrew C. Liu,Andrew C. Liu,Tsuyoshi Hirota,Tsuyoshi Hirota,Loren Miraglia,Genevieve Welch,Pagkapol Y. Pongsawakul,Xianzhong Liu,Ann Atwood,Jon W. Huss,Jeff Janes,Andrew I. Su,John B. Hogenesch,Steve A. Kay +15 more
TL;DR: The clock is interconnected with many aspects of cellular function and overrepresented genes are overrepresented for components of insulin and hedgehog signaling, the cell cycle, and the folate metabolism.
Journal ArticleDOI
An efficient rapid system for profiling the cellular activities of molecular libraries
Jonathan S. Melnick,Jeff Janes,Sungjoon Kim,Jim Yuchen Chang,Daniel G. Sipes,Drew Gunderson,Laura Jarnes,Jason T. Matzen,Michael Garcia,Tami Hood,Ronak Beigi,Gang Xia,Richard A. Harig,Hayk Asatryan,S. Frank Yan,Yingyao Zhou,Xiang-ju Gu,Alham Saadat,Vicki Zhou,Frederick J. King,Christopher M. Shaw,Andrew I. Su,Robert T. Downs,Nathanael S. Gray,Peter G. Schultz,Markus Warmuth,Jeremy S. Caldwell +26 more
TL;DR: A robotic system, termed the automated compound profiler, capable of both propagating a large number of cell lines in parallel and assaying large collections of molecules simultaneously against a matrix of cellular assays in a highly reproducible manner is described.
Journal ArticleDOI
The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis.
Jeff Janes,Megan E Young,Emily I. Chen,Nicole H Rogers,Sebastian Burgstaller-Muehlbacher,Laura D. Hughes,Melissa S. Love,Mitchell V. Hull,Kelli Kuhen,Ashley K. Woods,Sean B. Joseph,H. Michael Petrassi,Case W. McNamara,Matthew S. Tremblay,Andrew I. Su,Peter G. Schultz,Arnab Chatterjee +16 more
TL;DR: A comprehensive open-access, drug repositioning screening set of 12,000 compounds that was assembled by combining three widely used commercial drug competitive intelligence databases, together with extensive patent mining of small molecules that have been dosed in humans.