Achim Brinker

TL;DR: An efficient and robust high-throughput cell-based screen based on proliferation of Plasmodium falciparum in erythrocytes, which identified most known antimalarials and many novel chemical scaffolds, which likely act through both known and novel pathways.

TL;DR: Evidence is provided that GSK-3β is involved in the induction of mammalian neurogenesis in ESCs, and this and such other molecules are likely to provide insights into the molecular mechanisms that control stem cell fate, and may ultimately be useful to in vivo stem cell biology and therapy.

TL;DR: A sensitive approach based on multidimensional liquid chromatography/mass spectrometry is described that enables the rapid identification of numerous sites of tyrosine phosphorylation on a number of different proteins from human whole cell lysates to enable the rapid generation of new insights into signaling pathways as they occur in states of health and disease.

TL;DR: In vivo incorporation of isotopically labeled unnatural amino acids into large proteins drastically reduces the complexity of nuclear magnetic resonance (NMR) spectra and establishes a new avenue for the site-specific labeling of proteins at individual residues without altering the protein sequence.

TL;DR: The conclusions from these initial analyses are that the optimal blood preparation method is variable between analytes and that the discovery of blood proteins by MS can be extended to concentrations below the ng/mL range under certain circumstances.