K
Kithsiri Herath
Researcher at Merck & Co.
Publications - 75
Citations - 3810
Kithsiri Herath is an academic researcher from Merck & Co.. The author has contributed to research in topics: Platensimycin & Lipogenesis. The author has an hindex of 31, co-authored 75 publications receiving 3549 citations. Previous affiliations of Kithsiri Herath include Instituto Nacional de Biodiversidad & New York Botanical Garden.
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Journal ArticleDOI
Platensimycin is a selective FabF inhibitor with potent antibiotic properties
Jun Wang,Stephen M. Soisson,Katherine Young,Wesley L. Shoop,Wesley L. Shoop,Srinivas Kodali,Andrew Galgoci,Ronald E. Painter,Gopalakrishnan Parthasarathy,Yui S. Tang,Richard D. Cummings,Sookhee Ha,Karen Dorso,Mary Motyl,Hiranthi Jayasuriya,John G. Ondeyka,Kithsiri Herath,Chaowei Zhang,Lorraine D. Hernandez,John J. Allocco,Angela Basilio,José R. Tormo,Olga Genilloud,Francisca Vicente,Fernando Pelaez,Lawrence F. Colwell,Sang Ho Lee,B.F. Michael,Thomas J. Felcetto,Charles Gill,Lynn L. Silver,Lynn L. Silver,Jeffery D. Hermes,Ken Bartizal,John F. Barrett,Dennis M. Schmatz,Joseph W. Becker,Doris F. Cully,Sheo B. Singh +38 more
TL;DR: Platensimycin demonstrates strong, broad-spectrum Gram-positive antibacterial activity by selectively inhibiting cellular lipid biosynthesis through the selective targeting of β-ketoacyl-(acyl-carrier-protein (ACP) in the synthetic pathway of fatty acids.
Journal ArticleDOI
Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties.
Jun Wang,Srinivas Kodali,Sang Ho Lee,Andrew Galgoci,Ronald E. Painter,Karen Dorso,Fred Racine,Mary Motyl,Lorraine D. Hernandez,Elizabeth Tinney,Steven L. Colletti,Kithsiri Herath,Richard D. Cummings,Oscar Salazar,Ignacio González,Angela Basilio,Francisca Vicente,Olga Genilloud,Fernando Pelaez,Hiranthi Jayasuriya,Katherine Young,Doris F. Cully,Sheo B. Singh +22 more
TL;DR: Platencin shows potent in vivo efficacy without any observed toxicity, emphasizing the fact that more antibiotics with novel structures and new modes of action can be discovered by using this antisense differential sensitivity whole-cell screening paradigm.
Journal ArticleDOI
Isolation, structure, and absolute stereochemistry of platensimycin, a broad spectrum antibiotic discovered using an antisense differential sensitivity strategy.
Sheo B. Singh,Hiranthi Jayasuriya,John G. Ondeyka,Kithsiri Herath,Chaowei Zhang,Deborah L. Zink,Nancy N. Tsou,Richard G. Ball,Angela Basilio,Olga Genilloud,Maria Teresa Diez,Francisca Vicente,Fernando Pelaez,Katherine Young,Jun Wang +14 more
TL;DR: It was determined that potential reactivity of the enone moiety does not play a key role in the biological activity of platensimycin and cyclohexenone ring conformation renders for the stronger binding interaction with the enzyme.
Journal ArticleDOI
Discovery of a Small Molecule That Inhibits Cell Division by Blocking FtsZ, a Novel Therapeutic Target of Antibiotics *
Jun Wang,Andrew Galgoci,Srinivas Kodali,Kithsiri Herath,Hiranthi Jayasuriya,Karen Dorso,Francisca Vicente,Antonio Gonzalez,Doris F. Cully,David Bramhill,Sheo B. Singh +10 more
TL;DR: Viriditoxin exhibited broad-spectrum antibacterial activity against clinically relevant Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci, without affecting the viability of eukaryotic cells.
Journal ArticleDOI
Discovery of FabH/FabF Inhibitors from Natural Products
Katherine Young,Hiranthi Jayasuriya,John G. Ondeyka,Kithsiri Herath,Chaowei Zhang,Srinivas Kodali,Andrew Galgoci,Ronald E. Painter,Vickie Brown-Driver,Robert T. Yamamoto,Lynn L. Silver,Yingcong Zheng,Judith I. Ventura,Janet M. Sigmund,Sookhee Ha,Angela Basilio,Francisca Vicente,José R. Tormo,Fernando Pelaez,Phil Youngman,Doris F. Cully,John F. Barrett,Dennis M. Schmatz,Sheo B. Singh,Jun Wang +24 more
TL;DR: The mechanism of decreased target protein production by expression of antisense RNA was investigated using Northern blotting and revealed that the antisenseRNA acts posttranscriptionally by targeting mRNA, leading to 5′ mRNA degradation.