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Richard J. Auchus
Researcher at University of Michigan
Publications - 165
Citations - 11194
Richard J. Auchus is an academic researcher from University of Michigan. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 44, co-authored 118 publications receiving 10112 citations. Previous affiliations of Richard J. Auchus include University of Texas Southwestern Medical Center & University of California, San Francisco.
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The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders.
TL;DR: Understanding steroidogenesis is of fundamental importance to understanding disorders of sexual differentiation, reproduction, fertility, hypertension, obesity, and physiological homeostasis.
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Position statement: Utility, limitations, and pitfalls in measuring testosterone: An endocrine society position statement
TL;DR: Evaluated clinical assays for total and free testosterone showed that laboratory proficiency testing should be based on the ability to measure accurately and precisely samples containing known concentrations of testosterone, not only on agreement with others using the same method.
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Cytochrome b5 augments the 17,20-lyase activity of human P450c17 without direct electron transfer.
TL;DR: The data suggest that humanb 5 acts principally as an allosteric effector that interacts primarily with the P450c17·OR complex to stimulate 17,20-lyase activity.
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Identification of Ligands for DAF-12 that Govern Dauer Formation and Reproduction in C. elegans
Daniel L. Motola,Carolyn L. Cummins,Veerle Rottiers,Kamalesh K. Sharma,Tingting Li,Yong Li,Kelly Suino-Powell,H. Eric Xu,Richard J. Auchus,Adam Antebi,David J. Mangelsdorf +10 more
TL;DR: The first steroid hormones in nematodes are defined as ligands for an invertebrate orphan nuclear receptor and demonstrate that steroidal regulation of reproduction, from biology to molecular mechanism, is conserved from worms to humans.
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Estrogen: consequences and implications of human mutations in synthesis and action.
TL;DR: Study of the mutations in CYP19, the gene encoding aromatase, in six females and two males and a mutant estrogen receptor alpha in a man provide illuminating new insights into the critical role of estrogen in the male in the pubertal growth spurt and skeletal maturation, and in the importance of estrogen sufficiency in the accrual and maintenance of bone mass.