Position statement: Utility, limitations, and pitfalls in measuring testosterone: An endocrine society position statement
TLDR
Evaluated clinical assays for total and free testosterone showed that laboratory proficiency testing should be based on the ability to measure accurately and precisely samples containing known concentrations of testosterone, not only on agreement with others using the same method.Abstract:
Objective: The objective of the study was to evaluate the current state of clinical assays for total and free testosterone. Participants: The five participants were appointed by the Council of The Endocrine Society and charged with attaining the objective using published data and expert opinion. Evidence: Data were gleaned from published sources via online databases (principally PubMed, Ovid MEDLINE, Google Scholar), the College of American Pathologists, and the clinical and laboratory experiences of the participants. Consensus Process: The statement was an effort of the committee and was reviewed in detail by each member. The Council of The Endocrine Society reviewed a late draft and made specific recommendations. Conclusions: Laboratory proficiency testing should be based on the ability to measure accurately and precisely samples containing known concentrations of testosterone, not only on agreement with others using the same method. When such standardization is in place, normative values for total and ...read more
Citations
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Pathophysiology of Human Visceral Obesity: An Update
TL;DR: In clinical practice, measuring waist circumference in addition to the body mass index could be helpful for the identification and management of a subgroup of overweight or obese patients at high cardiometabolic risk.
Journal ArticleDOI
Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline.
Shalender Bhasin,Glenn R. Cunningham,Frances J. Hayes,Alvin M. Matsumoto,Peter J. Snyder,Ronald S. Swerdloff,Victor M. Montori +6 more
TL;DR: The guidelines for the evaluation and treatment of androgen deficiency syndromes in adult men published previously in 2006 were updated by the Task Force of the Clinical Guidelines Subcommittee of The Endocrine Society.
Journal ArticleDOI
The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report
Ricardo Azziz,Enrico Carmina,Didier Dewailly,Evanthia Diamanti-Kandarakis,Héctor F. Escobar-Morreale,Walter Futterweit,Onno E. Janssen,Richard S. Legro,Robert J. Norman,Ann Taylor,Selma F. Witchel +10 more
TL;DR: It is the view of the AE-PCOS Society Task Force that PCOS should be defined by the presence of hyperandrogenism, ovarian dysfunction, and/or polycystic ovaries, and the exclusion of related disorders.
Journal ArticleDOI
Diagnosis and treatment of polycystic ovary syndrome: an Endocrine Society clinical practice guideline.
Richard S. Legro,Silva A. Arslanian,David A. Ehrmann,Kathleen M. Hoeger,M. Hassan Murad,Renato Pasquali,Corrine K. Welt +6 more
TL;DR: Evaluation of women with PCOS should exclude alternate androgen-excess disorders and risk factors for endometrial cancer, mood disorders, obstructive sleep apnea, diabetes, and cardiovascular disease.
Journal ArticleDOI
Insulin Resistance and the Polycystic Ovary Syndrome Revisited: An Update on Mechanisms and Implications
TL;DR: In this paper, the authors summarized the state of the science since the last review in the Endocrine Reviews in 1997, and concluded that obese women with PCOS are insulin resistant, but some groups of lean affected women may have normal insulin sensitivity.
References
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A Critical Evaluation of Simple Methods for the Estimation of Free Testosterone in Serum
TL;DR: The FT value, obtained by calculation from T and SHBG as determined by immunoassay, appears to be a rapid, simple, and reliable index of bioavailable T, comparable to AFTC and suitable for clinical routine, except in pregnancy.
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Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men
TL;DR: Observations of health factor independent, age-related longitudinal decreases in T and free T, resulting in a high frequency of hypogonadal values, suggest that further investigation of T replacement in aged men, perhaps targeted to those with the lowest serum T concentrations, are justified.
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Position statement: Criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: An androgen excess society guideline
Ricardo Azziz,Enrico Carmina,Didier Dewailly,Evanthia Diamanti-Kandarakis,Héctor F. Escobar-Morreale,Walter Futterweit,Onno E. Janssen,Richard S. Legro,Robert J. Norman,Ann Taylor,Selma F. Witchel +10 more
TL;DR: It is the view of the AES Task Force on the Phenotype of PCOS that there should be acceptance of the original 1990 National Institutes of Health criteria with some modifications, taking into consideration the concerns expressed in the proceedings of the 2003 Rotterdam conference.
Journal ArticleDOI
Sex-hormone-binding globulin.
TL;DR: By developing SHBG concentration measurement methods-responses of hirsutism to glucocorticoid or estrogem may be assessed, and the effect of thyroid hormones on SHBG may also have therapeutic implications in endocrine disease.
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Calculation of free and bound fractions of testosterone and estradiol-17 beta to human plasma proteins at body temperature.
TL;DR: A mathematical model for the calculation of free and protein bound concentrations of testosterone and estradiol in plasma is presented and it was concluded that the androgen metabolites could be omitted from the calculations without affecting the calculated concentrations.