抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

The unity and diversity of executive functions and their contributions to complex "Frontal Lobe" tasks: a latent variable analysis.

In this article, the author describes a new theoretical perspective on positive emotions and situates this new perspective within the emerging field of positive psychology. The broaden-and-build theory posits that experiences of positive emotions broaden people's momentary thought-action repertoires, which in turn serves to build their enduring personal resources, ranging from physical and intellectual resources to social and psychological resources. Preliminary empirical evidence supporting the broaden-and-build theory is reviewed, and open empirical questions that remain to be tested are identified. The theory and findings suggest that the capacity to experience positive emotions may be a fundamental human strength central to the study of human flourishing.

http://www.elaborer.org/cours/A13/lectures/Fredrickson2001.pdf

The role of positive emotions in positive psychology. The broaden-and-build theory of positive emotions.

Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268

Many prominent theorists have argued that accurate perceptions of the self, the world, and the future are essential for mental health. Yet considerable research evidence suggests that overly positive selfevaluations, exaggerated perceptions of control or mastery, and unrealistic optimism are characteristic of normal human thought. Moreover, these illusions appear to promote other criteria of mental health, including the ability to care about others, the ability to be happy or contented, and the ability to engage in productive and creative work. These strategies may succeed, in large part, because both the social world and cognitive-processing mechanisms impose niters on incoming information that distort it in a positive direction; negative information may be isolated and represented in as unthreatening a manner as possible. These positive illusions may be especially useful when an individual receives negative feedback or is otherwise threatened and may be especially adaptive under these circumstances. Decades of psychological wisdom have established contact with reality as a hallmark of mental health. In this view, the well-adjusted person is thought to engage in accurate reality testing, whereas the individual whose vision is clouded by illusion is regarded as vulnerable to, if not already a victim of, mental illness. Despite its plausibility, this viewpoint is increasingly difficult to maintain (cf. Lazarus, 1983). A substantial amount of research testifies to the prevalence of illusion in normal human cognition (see Fiske& Taylor, 1984;Greenwald, 1980; Nisbett & Ross, 1980; Sackeim, 1983; Taylor, 1983). Moreover, these illusions often involve central aspects of the self and the environment and, therefore, cannot be dismissed as inconsequential. In this article, we review research suggesting that certain illusions may be adaptive for mental health and well-being. In particular, we examine evidence that a set of interrelated positive illusions—namely, unrealistically positive self-evaluations, exaggerated perceptions of control or mastery, and unrealistic optimism—can serve a wide variety of cognitive, affective, and social functions. We also attempt to resolve the following para

/pdf/illusion-and-well-being-a-social-psychological-perspective-5acx7rw6hx.pdf

Illusion and well-being: a social psychological perspective on mental health

Brain Regions Associated with the Expression and Contextual Regulation of Anxiety in Primates

The overall goal of this essay is to explore the initial findings of neuroscientific research on meditation; in doing so, the essay also suggests potential avenues of further inquiry. The essay consists of three sections that, while integral to the essay as a whole, may also be read independently. The first section, “Defining Meditation,” notes the need for a more precise understanding of meditation as a scientific explanandum. Arguing for the importance of distinguishing the particularities of various traditions, the section presents the theory of meditation from the paradigmatic perspective of Buddhism, and it discusses the difficulties encountered when working with such theories. The section includes an overview of three practices that have been the subject of research, and it ends with a strategy for developing a questionnaire to more precisely define a practice under examination. The second section, “the Intersection of Neuroscience and Meditation,” explores some scientific motivations for the neuroscientific examination of meditation in terms of its potential impact on the brain and body of long-term practitioners. After an overview of the mechanisms of mind-body interaction, this section addresses the use of first-person expertise, especially in relation to the potential for research on the neural counterpart of subjective experience. In general terms, the section thus

/pdf/meditation-and-the-neuroscience-of-consciousness-4k5cz49ae9.pdf

Meditation and the neuroscience of consciousness

Four experiments testing fight-handed adult males examined interhemispheric transfer time (IHTT) estimation with visual evoked potentials (EPs) elicited in response to hemiretinal presentations of checkerboard-flash stimuli. Experiment 1 was a study of the relation between reaction time (RT) and EP measures of IHTT. EP measures provided more valid estimates than RT measures because more subjects showed IHTT in the direction of anatomical prediction. Experiment 2 showed that EPs derived from lateral occipital sites provided more valid and longer estimates of IHTT compared with EPs from medial occipital sites. Experiment 3 showed no difference between random versus blocked hemiretinal stimuli. Experiment 4 showed that IHTT derived with a linked-ears reference provided more valid estimates than IHTT derived with a mid-frontal reference and that small changes in stimulus eccentricity did not influence IHTT. The findings of these experiments indicate that noninvasive estimates of visual IHTT can be obtained in humans.

Visual evoked potential measures of interhemispheric transfer time in humans.

http://jamiehanson.org/files/2009_Bauer_BiologicalPsychiatry.pdf

Richard J. Davidson

Papers

Brain Regions Associated with the Expression and Contextual Regulation of Anxiety in Primates

Meditation and the neuroscience of consciousness

Visual evoked potential measures of interhemispheric transfer time in humans.

Cerebellar Volume and Cognitive Functioning in Children Who Experienced Early Deprivation

Electroencephalogram Asymmetry in Response to the Approach of a Stranger and Maternal Separation in 10-Month-Old Infants.