R
Richard N. Clayton
Researcher at Keele University
Publications - 118
Citations - 8946
Richard N. Clayton is an academic researcher from Keele University. The author has contributed to research in topics: Loss of heterozygosity & Adenoma. The author has an hindex of 52, co-authored 116 publications receiving 8544 citations. Previous affiliations of Richard N. Clayton include Diabetes Australia & University Hospitals of North Midlands NHS Trust.
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A paradigm shift in the monitoring of patients with acromegaly: last available growth hormone may overestimate risk.
Mark Sherlock,Mark Sherlock,Raoul C. Reulen,Aurora Aragon-Alonso,John Ayuk,John Ayuk,Richard N. Clayton,Michael C. Sheppard,Michael M. Hawkins,A. S. Bates,Paul M. Stewart +10 more
TL;DR: This study again highlights the limitations of IGF-I in predicting mortality and compared the last available GH/IGF-I analysis to a "time-dependent" and cumulative method during follow-up to assess risk of mortality in the West Midlands Acromegaly study.
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Does growth hormone releasing factor desensitize the somatotroph? Interpretation of responses of growth hormone during and after 10-hour infusion of GRF 1-29 amide in man.
TL;DR: Following 10‐GRF infusion, responses to bolus injection of GRF were reduced, but variable; in two subjects a small rise in GH levels occurred and in the other two subjects, GH levels fell but in these the GRF bolus had coincided with a GH peak.
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Monitoring disease activity using GH and IGF‐I in the follow‐up of 501 patients with acromegaly
Mark Sherlock,Aurora Aragon Alonso,Raoul C. Reulen,John Ayuk,Richard N. Clayton,Geoff Holder,Michael C. Sheppard,A. S. Bates,Paul M. Stewart +8 more
TL;DR: The aims of treatment in patients with acromegaly are to achieve serum GH/IGF‐I concentrations associated with cure or normalization of mortality and alleviation of symptoms.
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Altered composition of high density lipoproteins in women with the polycystic ovary syndrome
M. Rajkhowa,R. Neary,P. Kumpatla,Frances L. Game,Peter W. Jones,M. S. Obhrai,Richard N. Clayton +6 more
TL;DR: In this paper, a detailed exploratory study of HDL composition in 35 obese [body mass index (BMI), > 27] and 22 nonobese subjects with polycystic ovary syndrome (PCOS) was conducted in 14 healthy obese and 18 non-obese women.
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Clinical and genetic changes in a case of a Cushing's carcinoma
A. S. Bates,N. Buckley,M. D. Boggild,E. J. Bicknell,Christopher W. Perrett,John C. Broome,Richard N. Clayton +6 more
TL;DR: Molecular genetic analysis of tumour and metastatic tissue revealed loss of heterozygosity at loci on the autosomes 1p, 3p, 10q26,11q13 and 22q12, and tissue taken at surgery In 1986 also revealed positive cytoplasmic Immunostalning for p53 protein.