R
Richard S. Judson
Researcher at United States Environmental Protection Agency
Publications - 231
Citations - 25081
Richard S. Judson is an academic researcher from United States Environmental Protection Agency. The author has contributed to research in topics: High-Throughput Screening Assays & Population. The author has an hindex of 69, co-authored 220 publications receiving 22147 citations. Previous affiliations of Richard S. Judson include Sandia National Laboratories & University of Houston.
Papers
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Journal ArticleDOI
Perspectives on validation of high-throughput assays supporting 21st century toxicity testing.
Richard S. Judson,Robert J. Kavlock,Matthew T. Martin,David M. Reif,Keith A. Houck,Thomas B. Knudsen,Ann M. Richard,Raymond R. Tice,Maurice Whelan,Menghang Xia,Ruili Huang,Christopher M. Austin,George P. Daston,Thomas Hartung,John R. Fowle,William Wooge,Weida Tong,David J. Dix +17 more
TL;DR: Practical guidelines are discussed that follow current validation practice to the extent possible and practical; make increased use of reference compounds to better demonstrate assay reliability and relevance; and de-emphasize the need for cross-laboratory testing.
Journal ArticleDOI
Activity profiles of 309 ToxCast™ chemicals evaluated across 292 biochemical targets.
Thomas B. Knudsen,Keith A. Houck,Nisha S. Sipes,Amar V. Singh,Richard S. Judson,Matthew T. Martin,Arthur Weissman,Nicole Kleinstreuer,Holly M. Mortensen,David M. Reif,James R. Rabinowitz,R. Woodrow Setzer,Ann M. Richard,David J. Dix,Robert J. Kavlock +14 more
TL;DR: Mapping relationships across 93,440 chemical-assay pairs based on half-maximal activity concentration (AC50) revealed both known and novel targets in signaling and metabolic pathways.
Journal ArticleDOI
In Vitro and Modelling Approaches to Risk Assessment from the U.S. Environmental Protection Agency ToxCast Programme
Richard S. Judson,Keith A. Houck,Matthew T. Martin,Thomas B. Knudsen,Russell S. Thomas,Nisha S. Sipes,Imran Shah,John F. Wambaugh,Kevin M. Crofton +8 more
TL;DR: An overall strategy to deal with the 'too many chemicals' problem by the U.S. Environmental Protection Agency is described and briefly illustrated with recent examples from the ToxCast programme.
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Profiling the reproductive toxicity of chemicals from multigeneration studies in the toxicity reference database.
Matthew T. Martin,Elizabeth Mendez,Daniel G. Corum,Richard S. Judson,Robert J. Kavlock,Daniel M. Rotroff,David J. Dix +6 more
TL;DR: Results from 329 multigeneration studies on 316 chemicals have been digitized into standardized and structured toxicity data within the Toxicity Reference Database (ToxRefDB), which supports ongoing retrospective analyses, test guideline revisions, and computational toxicology research.
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Environmental impact on vascular development predicted by high-throughput screening.
Nicole Kleinstreuer,Richard S. Judson,David M. Reif,Nisha S. Sipes,Amar V. Singh,Kelly J. Chandler,Rob DeWoskin,David J. Dix,Robert J. Kavlock,Thomas B. Knudsen +9 more
TL;DR: It is predicted that blood vessel development is a target for environmental chemicals acting as putative vascular disruptor compounds (pVDCs) and identified potential species differences in sensitive vascular developmental pathways.