R
Richard S. Judson
Researcher at United States Environmental Protection Agency
Publications - 231
Citations - 25081
Richard S. Judson is an academic researcher from United States Environmental Protection Agency. The author has contributed to research in topics: High-Throughput Screening Assays & Population. The author has an hindex of 69, co-authored 220 publications receiving 22147 citations. Previous affiliations of Richard S. Judson include Sandia National Laboratories & University of Houston.
Papers
More filters
Journal ArticleDOI
The Tox21 10K Compound Library: Collaborative Chemistry Advancing Toxicology.
Ann M. Richard,Ruili Huang,Suramya Waidyanatha,Paul Shinn,Bradley J. Collins,Inthirany Thillainadarajah,Christopher M. Grulke,Antony J. Williams,Ryan Lougee,Ryan Lougee,Richard S. Judson,Keith A. Houck,Mahmoud Shobair,Chihae Yang,James F. Rathman,Adam Yasgar,Suzanne Fitzpatrick,Anton Simeonov,Russell S. Thomas,Kevin M. Crofton,Kevin M. Crofton,Richard S. Paules,John R. Bucher,Christopher P. Austin,Robert J. Kavlock,Raymond R. Tice +25 more
TL;DR: The history of development of the Tox21 “10K” chemical library and data workflows implemented to ensure quality chemical annotations and allow for various reproducibility assessments are described, supporting a central premise of theTox21 program.
Journal ArticleDOI
CoMPARA: Collaborative Modeling Project for Androgen Receptor Activity.
Kamel Mansouri,Nicole Kleinstreuer,Ahmed Abdelaziz,Domenico Alberga,Vinicius M. Alves,Vinicius M. Alves,Patrik L. Andersson,Carolina Horta Andrade,Fang Bai,Ilya A. Balabin,Davide Ballabio,Emilio Benfenati,Barun Bhhatarai,Scott Boyer,Jingwen Chen,Viviana Consonni,Sherif Farag,Denis Fourches,Alfonso T. García-Sosa,Paola Gramatica,Francesca Grisoni,Christopher M. Grulke,Huixiao Hong,Dragos Horvath,Xin Hu,Ruili Huang,Nina Jeliazkova,Jiazhong Li,Xuehua Li,Huanxiang Liu,Serena Manganelli,Giuseppe Felice Mangiatordi,Uko Maran,Gilles Marcou,Todd M. Martin,Eugene N. Muratov,Dac-Trung Nguyen,Orazio Nicolotti,Nikolai Georgiev Nikolov,Ulf Norinder,Ester Papa,Michel Petitjean,Geven Piir,Pavel V. Pogodin,Vladimir Poroikov,Xianliang Qiao,Ann M. Richard,Alessandra Roncaglioni,Patricia Ruiz,Chetan Rupakheti,Chetan Rupakheti,Sugunadevi Sakkiah,Alessandro Sangion,Karl-Werner Schramm,Chandrabose Selvaraj,Imran Shah,Sulev Sild,Lixia Sun,Olivier Taboureau,Yun Tang,Igor V. Tetko,Roberto Todeschini,Weida Tong,Daniela Trisciuzzi,Alexander Tropsha,George Van Den Driessche,Alexandre Varnek,Zhongyu Wang,Eva Bay Wedebye,Antony J. Williams,Hongbin Xie,Alexey V. Zakharov,Ziye Zheng,Richard S. Judson +73 more
TL;DR: The Collaborative Modeling Project for Androgen Receptor Activity (CoMPARA) efforts are described, which follows the steps of the Collaborative Estrogen Recept Activity Prediction Project (CERAPP).
Journal ArticleDOI
Conformational searching methods for small molecules II: genetic algorithm approach
TL;DR: The use of a genetic algorithm (GA) search procedure for finding low‐energy conformations of small to medium organic molecules (1–12 rotatable bonds) is demonstrated and the performance against the CSEARCH algorithm in Sybyl is compared.
Journal ArticleDOI
Relative Impact of Incorporating Pharmacokinetics on Predicting In Vivo Hazard and Mode of Action From High-Throughput In Vitro Toxicity Assays
Barbara A. Wetmore,John F. Wambaugh,Stephen S. Ferguson,Lili Li,Harvey J. Clewell,Richard S. Judson,Kimberly Freeman,Wenjun Bao,Mark A. Sochaski,Tzu-Ming Chu,Michael B. Black,Eric Healy,Brittany Allen,Melvin E. Andersen,Russell D. Wolfinger,Russell S. Thomas +15 more
TL;DR: Comparison of the oral equivalent doses for the in vitro assays with the in vivo dose range that resulted in adverse effects identified more coincident in vitro Assays across chemicals than expected by chance, suggesting that the approach may also be used to identify potential molecular initiating events leading to adversity.
Journal ArticleDOI
Aggregating data for computational toxicology applications: The U.S. Environmental Protection Agency (EPA) Aggregated Computational Toxicology Resource (ACToR) System.
Richard S. Judson,Matthew T. Martin,Peter P. Egeghy,Sumit Gangwal,David M. Reif,Parth Kothiya,Maritja Wolf,Tommy Cathey,Thomas R. Transue,Doris Smith,James Vail,Alicia M. Frame,Shad Mosher,Elaine A. Cohen Hubal,Ann M. Richard +14 more
TL;DR: The organization of the ACToR data repository is described and selected examples of use cases are provided, including links to underlying biological information related to genes and pathways.