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Richard S. Judson
Researcher at United States Environmental Protection Agency
Publications - 231
Citations - 25081
Richard S. Judson is an academic researcher from United States Environmental Protection Agency. The author has contributed to research in topics: High-Throughput Screening Assays & Population. The author has an hindex of 69, co-authored 220 publications receiving 22147 citations. Previous affiliations of Richard S. Judson include Sandia National Laboratories & University of Houston.
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Journal ArticleDOI
Prioritizing Environmental Chemicals for Obesity and Diabetes Outcomes Research: A Screening Approach Using ToxCast™ High-Throughput Data
Scott S. Auerbach,Dayne L. Filer,David M. Reif,Vickie R. Walker,Alison C. Holloway,Jennifer J. Schlezinger,Supriya Srinivasan,Daniel L. Svoboda,Richard S. Judson,John R. Bucher,Kristina A. Thayer +10 more
TL;DR: The results of this screening-level analysis suggest that the spectrum of environmental chemicals to consider in research related to diabetes and obesity is much broader than indicated by research papers and reviews published in the peer-reviewed literature.
Journal ArticleDOI
Challenges in IBD Research: Environmental Triggers.
Shuk-Mei Ho,James D. Lewis,Emeran A. Mayer,Charles N. Bernstein,Scott E. Plevy,Emil Chuang,Stephen M. Rappaport,Kenneth Croitoru,Joshua R. Korzenik,Jeffrey P. Krischer,Jeffrey S. Hyams,Richard S. Judson,Manolis Kellis,Michael Jerrett,Gary W. Miller,Melanie L Grant,Nataly Shtraizent,Gerard Honig,Andrés Hurtado-Lorenzo,Gary D. Wu +19 more
TL;DR: The implementation of longitudinal prospective studies to determine disease evolution and identify sub-clinical changes in response to exposures is proposed, which can help define critical windows of vulnerability and risk prediction and lead to identification of biomarkers of exposures and new modalities for therapeutic intervention.
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Using Nuclear Receptor Activity to Stratify Hepatocarcinogens
Imran Shah,Keith A. Houck,Richard S. Judson,Robert J. Kavlock,Matthew T. Martin,David M. Reif,John F. Wambaugh,David J. Dix +7 more
TL;DR: These results do not prove the role of NR activation in human liver cancer, but they do have implications for nuclear receptor chemical biology and provide insights into putative toxicity pathways and suggest the utility of in vitro assays for stratifying environmental contaminants based on a combination of human bioactivity and rodent toxicity.
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Systems Toxicology of Male Reproductive Development: Profiling 774 Chemicals for Molecular Targets and Adverse Outcomes
Maxwell C.K. Leung,Jimmy Phuong,Nancy C. Baker,Nisha S. Sipes,Nisha S. Sipes,Gary R. Klinefelter,Matthew T. Martin,Keith W. McLaurin,Keith W. McLaurin,R. Woodrow Setzer,Sally Perreault Darney,Sally Perreault Darney,Richard S. Judson,Thomas B. Knudsen +13 more
TL;DR: Computational modeling of available in vivo and in vitro data for chemicals that produce adverse effects on male reproductive end points revealed a phenotypic hierarchy across animal studies consistent with the human testicular dysgenesis syndrome (TDS) hypothesis.
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Considerations for Strategic Use of High-Throughput Transcriptomics Chemical Screening Data in Regulatory Decisions.
Joshua A. Harrill,Imran Shah,R. Woodrow Setzer,Derik E. Haggard,Scott S. Auerbach,Richard S. Judson,Russell S. Thomas +6 more
TL;DR: This work discusses study design considerations for HTTr concentration-response screening and presents a framework for the use of HTTr-based biological pathway-altering concentrations (BPACs) in a screening-level, risk-based chemical prioritization approach.