R
Ridham Desai
Researcher at Lunenfeld-Tanenbaum Research Institute
Publications - 2
Citations - 1991
Ridham Desai is an academic researcher from Lunenfeld-Tanenbaum Research Institute. The author has contributed to research in topics: Induced pluripotent stem cell & Neural stem cell. The author has an hindex of 2, co-authored 2 publications receiving 1921 citations. Previous affiliations of Ridham Desai include Mount Sinai Hospital, Toronto & University of Toronto.
Papers
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piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells
Knut Woltjen,Iacovos P. Michael,Iacovos P. Michael,Paria Mohseni,Paria Mohseni,Ridham Desai,Ridham Desai,Maria Mileikovsky,Riikka H. Hämäläinen,Rebecca Cowling,Wei Wang,Pentao Liu,Marina Gertsenstein,Keisuke Kaji,Hoon Ki Sung,Andras Nagy,Andras Nagy +16 more
TL;DR: It is shown that the individual PB insertions can be removed from established iPS cell lines, providing an invaluable tool for discovery, and the traceless removal of reprogramming factors joined with viral 2A sequences delivered by a single transposon from murine iPS lines is demonstrated.
Journal ArticleDOI
Lin28 promotes the proliferative capacity of neural progenitor cells in brain development
Mei Yang,Si Lu Yang,Stephanie Herrlinger,Chen Liang,Monika Dzieciatkowska,Kirk C. Hansen,Ridham Desai,Andras Nagy,Lee Niswander,Eric G. Moss,Jian-Fu Chen +10 more
TL;DR: The proliferation of neural progenitor cells is regulated by Lin28a/b via their interaction with Imp1 and their regulation of Igf2-mTOR signaling, which is attributed to the regulation of their mRNA targets that encode Igf1r and Hmga2.