H
Hoon Ki Sung
Researcher at University of Toronto
Publications - 61
Citations - 7151
Hoon Ki Sung is an academic researcher from University of Toronto. The author has contributed to research in topics: Adipose tissue & Induced pluripotent stem cell. The author has an hindex of 23, co-authored 49 publications receiving 6269 citations. Previous affiliations of Hoon Ki Sung include Mount Sinai Hospital, Toronto & Yeungnam University.
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Journal ArticleDOI
piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells
Knut Woltjen,Iacovos P. Michael,Iacovos P. Michael,Paria Mohseni,Paria Mohseni,Ridham Desai,Ridham Desai,Maria Mileikovsky,Riikka H. Hämäläinen,Rebecca Cowling,Wei Wang,Pentao Liu,Marina Gertsenstein,Keisuke Kaji,Hoon Ki Sung,Andras Nagy,Andras Nagy +16 more
TL;DR: It is shown that the individual PB insertions can be removed from established iPS cell lines, providing an invaluable tool for discovery, and the traceless removal of reprogramming factors joined with viral 2A sequences delivered by a single transposon from murine iPS lines is demonstrated.
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Obesity-associated variants within FTO form long-range functional connections with IRX3
Scott Smemo,Juan J. Tena,Kyoung-Han Kim,Eric R. Gamazon,Noboru J. Sakabe,Carlos Gómez-Marín,Ivy Aneas,Flavia L. Credidio,Débora R. Sobreira,Nora F. Wasserman,Ju Hee Lee,Vijitha Puviindran,Davis Tam,Michael Shen,Joe Eun Son,Niki Alizadeh Vakili,Hoon Ki Sung,Silvia Naranjo,Rafael D. Acemel,Miguel Manzanares,Andras Nagy,Nancy J. Cox,Chi-chung Hui,José Luis Gómez-Skarmeta,Marcelo A. Nobrega +24 more
TL;DR: It is shown that the obesity-associated noncoding sequences within FTO are functionally connected, at megabase distances, with the homeobox gene IRX3, and long-range enhancers within this region recapitulate aspects of IRx3 expression, suggesting that the Obesity-associated interval belongs to the regulatory landscape ofIRX3.
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Functional Genomics Reveals a BMP-Driven Mesenchymal-to-Epithelial Transition in the Initiation of Somatic Cell Reprogramming
Payman Samavarchi-Tehrani,Azadeh Golipour,Azadeh Golipour,Laurent David,Hoon Ki Sung,Tobias A. Beyer,Alessandro Datti,Knut Woltjen,Andras Nagy,Andras Nagy,Jeffrey L. Wrana,Jeffrey L. Wrana +11 more
TL;DR: A multistep mechanism that incorporates a BMP-miRNA-MET axis during somatic cell reprogramming is defined that is linked to B MP-dependent induction of miR-205 and themiR-200 family of microRNAs that are key regulators of MET.
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An Alternative Splicing Switch Regulates Embryonic Stem Cell Pluripotency and Reprogramming
Mathieu Gabut,Payman Samavarchi-Tehrani,Payman Samavarchi-Tehrani,Xinchen Wang,Valentina Slobodeniuc,Dave O'Hanlon,Hoon Ki Sung,Manuel Alvarez,Shaheynoor Talukder,Qun Pan,Esteban O. Mazzoni,Stéphane Nedelec,Hynek Wichterle,Knut Woltjen,Timothy P. Hughes,Peter W. Zandstra,Andras Nagy,Andras Nagy,Jeffrey L. Wrana,Jeffrey L. Wrana,Benjamin J. Blencowe +20 more
TL;DR: It is shown that the ESC-specific isoform of FOXP1 stimulates the expression of transcription factor genes required for pluripotency, including OCT4, NANOG, NR5A2, and GDF3, while concomitantly repressing genes necessary for ESC differentiation.
Journal ArticleDOI
MBNL proteins repress ES-cell-specific alternative splicing and reprogramming
Hong Han,Manuel Irimia,P. Joel Ross,Hoon Ki Sung,Babak Alipanahi,Laurent David,Azadeh Golipour,Azadeh Golipour,Mathieu Gabut,Iacovos P. Michael,Emil N. Nachman,Eric T. Wang,Dan Trcka,Tadeo Thompson,Dave O'Hanlon,Valentina Slobodeniuc,Nuno L. Barbosa-Morais,Nuno L. Barbosa-Morais,Christopher B. Burge,Jason Moffat,Brendan J. Frey,Andras Nagy,Andras Nagy,James Ellis,Jeffrey L. Wrana,Jeffrey L. Wrana,Benjamin J. Blencowe +26 more
TL;DR: MBNL proteins are identified as conserved and direct negative regulators of a large program of cassette exon alternative splicing events that are differentially regulated between ES cells and other cell types, consistent with a central and negative regulatory role for MBNL proteins in pluripotency.