R
Riikka H. Hämäläinen
Researcher at University of Eastern Finland
Publications - 47
Citations - 5108
Riikka H. Hämäläinen is an academic researcher from University of Eastern Finland. The author has contributed to research in topics: Induced pluripotent stem cell & Mitochondrial DNA. The author has an hindex of 21, co-authored 41 publications receiving 4598 citations. Previous affiliations of Riikka H. Hämäläinen include University of Helsinki & Mount Sinai Hospital, Toronto.
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Journal ArticleDOI
piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells
Knut Woltjen,Iacovos P. Michael,Iacovos P. Michael,Paria Mohseni,Paria Mohseni,Ridham Desai,Ridham Desai,Maria Mileikovsky,Riikka H. Hämäläinen,Rebecca Cowling,Wei Wang,Pentao Liu,Marina Gertsenstein,Keisuke Kaji,Hoon Ki Sung,Andras Nagy,Andras Nagy +16 more
TL;DR: It is shown that the individual PB insertions can be removed from established iPS cell lines, providing an invaluable tool for discovery, and the traceless removal of reprogramming factors joined with viral 2A sequences delivered by a single transposon from murine iPS lines is demonstrated.
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Copy number variation and selection during reprogramming to pluripotency
Samer M.I. Hussein,Nizar N. Batada,Sanna Vuoristo,Reagan W. Ching,Reija Autio,Reija Autio,Elisa Närvä,Siemon Ng,Michel Sourour,Riikka H. Hämäläinen,Cia Olsson,Karolina Lundin,Milla Mikkola,Ras Trokovic,Michael Peitz,Oliver Brüstle,David P. Bazett-Jones,Kari Alitalo,Riitta Lahesmaa,Andras Nagy,Timo Otonkoski +20 more
TL;DR: It is shown that significantly more CNVs are present in early-passage human iPS cells than intermediate passage human i PS cells, fibroblast cell origins and with human embryonic stem (ES) cells.
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Exome Sequencing Identifies Mitochondrial Alanyl-tRNA Synthetase Mutations in Infantile Mitochondrial Cardiomyopathy
Alexandra Götz,Henna Tyynismaa,Liliya Euro,Pekka Ellonen,Tuulia Hyötyläinen,Tiina Ojala,Riikka H. Hämäläinen,Johanna Tommiska,Johanna Tommiska,Taneli Raivio,Taneli Raivio,Matej Orešič,Riitta Karikoski,Riitta Karikoski,Outi Tammela,Kalle O. J. Simola,Anders Paetau,Anders Paetau,Tiina Tyni,Tiina Tyni,Anu Suomalainen,Anu Suomalainen +21 more
TL;DR: It is shown that mutations in AARS2 cause perinatal or infantile cardiomyopathy with near-total combined mitochondrial respiratory chain deficiency in the heart and that mitochondrial disorders extend to prenatal life and are an important cause of early infantile cardiac failure.
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Somatic Progenitor Cell Vulnerability to Mitochondrial DNA Mutagenesis Underlies Progeroid Phenotypes in Polg Mutator Mice
Kati J. Ahlqvist,Riikka H. Hämäläinen,Shuichi Yatsuga,Marko Uutela,Mügen Terzioglu,Alexandra Götz,Saara Forsström,Petri Salven,Alexandre Angers-Loustau,Outi H. Kopra,Henna Tyynismaa,Nils-Göran Larsson,Kirmo Wartiovaara,Tomas A. Prolla,Aleksandra Trifunovic,Anu Suomalainen +15 more
TL;DR: This work proposes that SSC compartment is sensitive to mtDNA mutagenesis, and that mitochondrial dysfunction in SSCs can underlie progeroid manifestations, and proposes that N-acetyl-L-cysteine treatment rescued both NSC and HPC abnormalities.
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The gene disrupted in Marinesco-Sjögren syndrome encodes SIL1, an HSPA5 cochaperone
Anna-Kaisa Anttonen,Ibrahim Mahjneh,Riikka H. Hämäläinen,Clotilde Lagier-Tourenne,Outi Kopra,Laura Waris,Mikko Anttonen,Tarja Joensuu,Hannu Kalimo,Anders Paetau,Lisbeth Tranebjærg,Denys Chaigne,Michel Koenig,Orvar Eeg-Olofsson,Bjarne Udd,Mirja Somer,Hannu Somer,Anna-Elina Lehesjoki +17 more
TL;DR: The identified gene underlying Marinesco-Sjögren syndrome, which is characterized by cerebellar ataxia, progressive myopathy and cataracts, and four disease-associated, predicted loss-of-function mutations in SIL1, which encodes a nucleotide exchange factor for the heat-shock protein 70 (HSP70) chaperone HSPA5.