R
Riitta Koistinen
Researcher at Helsinki University Central Hospital
Publications - 101
Citations - 5144
Riitta Koistinen is an academic researcher from Helsinki University Central Hospital. The author has contributed to research in topics: Glycodelin & Insulin. The author has an hindex of 41, co-authored 100 publications receiving 4985 citations. Previous affiliations of Riitta Koistinen include Monash University, Clayton campus.
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Structural analysis of the oligosaccharides derived from glycodelin, a human glycoprotein with potent immunosuppressive and contraceptive activities.
Anne Dell,Howard R. Morris,Richard L. Easton,Maria Panico,Manish S. Patankar,Sergio Oehninger,Riitta Koistinen,Hannu Koistinen,Markku Seppälä,Gary F. Clark +9 more
TL;DR: The potent inhibitory effect of glycodelin on initial human sperm-zona pellucida binding is consistent with previous suggestion that this cell adhesion event requires a selectin-like adhesion process and raises the possibility that a convergence between immune and gamete recognition processes may have occurred in the types of carbohydrate ligands recognized in the human.
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Glycodelin: A Major Lipocalin Protein of the Reproductive Axis with Diverse Actions in Cell Recognition and Differentiation
TL;DR: Along with being an epithelial differentiation marker, glycodelin appears to play a role in glandular morphogenesis, as transfection of gly codelin cDNA into a glyCodelin-negative breast cancer cells resulted in formation of gland-like structures, restricted proliferation, and induction of other epithelial markers.
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Suppression by human placental protein 14 of natural killer cell activity.
Norihiko Okamoto,Atsushi Uchida,K. Takakura,Yoshitaka Kariya,Hideharu Kanzaki,Leena Riittinen,Riitta Koistinen,Markku Seppälä,T. Mori +8 more
TL;DR: Results indicate that PP14 suppresses the function of NK cells, which might be involved in prevention of maternal immune rejection of fetus at the fetomaternal interface.
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Placental protein 12 is a decidual protein that binds somatomedin and has an identical N-terminal amino acid sequence with somatomedin-binding protein from human amniotic fluid.
Riitta Koistinen,Nisse Kalkkinen,Marja-Liisa Huhtala,Markku Seppälä,Hans Bohn,Eeva-Marja Rutanen +5 more
TL;DR: Data show that PP12 is a somatomedin-binding protein and extend through previous literature on PP12 the existing knowledge on the physiology and pathophysiology of somatOMD protein(s) in human reproduction and cancer.
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Secretory endometrium synthesizes placental protein 14.
Mervi Julkunen,Riitta Koistinen,Jari Sjöberg,Eeva-Marja Rutanen,Torsten Wahlström,Markku Seppälä +5 more
TL;DR: Results show that PP14 is synthesized and secreted by the nonpregnant endometrium, and cycloheximide markedly decreased this release.