J
Jari Sjöberg
Researcher at University of Helsinki
Publications - 64
Citations - 4828
Jari Sjöberg is an academic researcher from University of Helsinki. The author has contributed to research in topics: Hysterectomy & Ovary. The author has an hindex of 32, co-authored 62 publications receiving 4440 citations. Previous affiliations of Jari Sjöberg include Helsinki University Central Hospital & Royal North Shore Hospital.
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Journal ArticleDOI
MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas.
Netta Mäkinen,Miika Mehine,Jaana Tolvanen,Eevi Kaasinen,Yang Li,Heli J. Lehtonen,Massimiliano Gentile,Jian Yan,Martin Enge,Minna Taipale,Minna Taipale,Mervi Aavikko,Riku Katainen,Elina Virolainen,Tom Böhling,Tom Böhling,Taru A. Koski,Virpi Launonen,Jari Sjöberg,Jussi Taipale,Jussi Taipale,Pia Vahteristo,Lauri A. Aaltonen +22 more
TL;DR: It is determined that MED12 is altered in 70% (159 of 225) of tumors from a total of 80 patients, and aberrant function of this region of MED12 contributes to tumorigenesis.
Journal ArticleDOI
Morbidity of 10 110 hysterectomies by type of approach
Juha Mäkinen,Jari Johansson,Candido Tomás,Eija Tomás,Pentti K. Heinonen,Timo Laatikainen,Minna Kauko,Anna-Mari Heikkinen,Jari Sjöberg +8 more
TL;DR: This large-scale observational study on hysterectomies provides novel information on operation-related morbidity of abdominal, vaginal or laparoscopic approach and supports the importance of the experience of the surgeon in reducing severe complications, especially in Laparoscopic and vaginal hysteretomies.
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Human growth differentiation factor 9 (GDF-9) and its novel homolog GDF-9B are expressed in oocytes during early folliculogenesis.
Johanna Aaltonen,Mika Laitinen,Kaisa Vuojolainen,Risto Jaatinen,Nina Horelli-Kuitunen,Laura Seppä,Henna Louhio,Timo Tuuri,Jari Sjöberg,Ralf Bützow,Outi Hovatta,Leslie Dale,Olli Ritvos +12 more
TL;DR: In situ hybridization and immunohistochemical analyses determine the localization of the GDF-9 messenger ribonucleic acid (mRNA) and protein during human folliculogenesis and conclude that both G DF-9 mRNA and protein are abundantly expressed in oocytes of primary follicles in human ovary, suggesting that the Gdf-9 transcript is translated at this early stage of follicULogenesis.
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Urinary Tract Injuries After Hysterectomy
TL;DR: The risk of ureteral injury is higher after laparoscopic hysterectomy compared with traditional hysteretomy, and the convalescence times after a bladder injury were 51 days, 118 days, 71 days, and 99 days after Laparoscopic, abdominal, supracervical abdominal, and vaginal hystmerectomy.
Journal ArticleDOI
Characterization of uterine leiomyomas by whole-genome sequencing.
Miika Mehine,Eevi Kaasinen,Netta Mäkinen,Riku Katainen,Kati Kämpjärvi,Esa Pitkänen,Hanna-Riikka Heinonen,Ralf Bützow,Outi Kilpivaara,Anna Kuosmanen,Heikki Ristolainen,Massimiliano Gentile,Jari Sjöberg,Pia Vahteristo,Lauri A. Aaltonen +14 more
TL;DR: Chromosome shattering and reassembly resembling chromothripsis is a major cause of chromosomal abnormalities in uterine leiomyomas and it is proposed that tumorigenesis occurs when tissue-specific tumor-promoting changes are formed through these events.