Glycodelin: A Major Lipocalin Protein of the Reproductive Axis with Diverse Actions in Cell Recognition and Differentiation
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TLDR
Along with being an epithelial differentiation marker, glycodelin appears to play a role in glandular morphogenesis, as transfection of gly codelin cDNA into a glyCodelin-negative breast cancer cells resulted in formation of gland-like structures, restricted proliferation, and induction of other epithelial markers.Abstract:
Glycodelin is a glycoprotein that belongs to the lipocalin superfamily. Depending on glycosylation, glycodelin appears in various isoforms. In the uterus, glycodelin-A is the major progesterone-regulated glycoprotein secreted into uterine luminal cavity by secretory/decidualized endometrial glands. The other tissues expressing glycodelin include fallopian tubes, ovary, breast, seminal vesicle, bone marrow, and eccrine glands. Glycodelin-A potently and dose-dependently inhibits human sperm-egg binding, whereas differently glycosylated glycodelin-S from seminal plasma has no such effect. Absence of contraceptive glycodelin-A in the uterus during periovulatory midcycle is consistent with an open “fertile window.” Glycodelin induced by local or systemic administration of progestogens may potentially reduce the fertilizing capacity of sperm in any phase of the menstrual cycle. Glycodelin also has immunosuppressive activity. Its high concentration at the fetomaternal interface may contribute to protection of th...read more
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Expression Profiling of Endometrium from Women with Endometriosis Reveals Candidate Genes for Disease-Based Implantation Failure and Infertility
L.C. Kao,Ariane Germeyer,Suzana Tulac,Shalini C Lobo,J. P. Yang,Robert N. Taylor,Kevin G. Osteen,Bruce A. Lessey,Linda C. Giudice +8 more
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Invited Review: β-Lactoglobulin: Binding Properties, Structure, and Function
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Endocrine regulation of menstruation.
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Pregnancy complications in women with polycystic ovary syndrome
Stefano Palomba,Marlieke A. de Wilde,Angela Falbo,Maria P.H. Koster,Giovanni Battista La Sala,Bart C.J.M. Fauser +5 more
TL;DR: The strategies for prevention and management of pregnancy complications in women with PCOS, and whether long-term health of these women is influenced, and to what extent, by pregnancy and/or pregnancy complications, remain to be elucidated are summarized.
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Natural Killer Cells in Pregnancy and Recurrent Pregnancy Loss: Endocrine and Immunologic Perspectives
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References
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