R
Ritwik Ghosh
Researcher at Vanderbilt University
Publications - 9
Citations - 611
Ritwik Ghosh is an academic researcher from Vanderbilt University. The author has contributed to research in topics: PI3K/AKT/mTOR pathway & Receptor tyrosine kinase. The author has an hindex of 7, co-authored 9 publications receiving 559 citations. Previous affiliations of Ritwik Ghosh include Vanderbilt University Medical Center.
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Journal ArticleDOI
Trastuzumab Has Preferential Activity against Breast Cancers Driven by HER2 Homodimers
Ritwik Ghosh,Archana Narasanna,Shizhen Emily Wang,Shuying Liu,Anindita Chakrabarty,Justin M. Balko,Ana M. Gonzalez-Angulo,Gordon B. Mills,Elicia Penuel,John Winslow,Jeff Sperinde,Rajiv Dua,Sailaja Pidaparthi,Ali Mukherjee,Kim Leitzel,Wolfgang J. Köstler,Allan Lipton,Michael Bates,Carlos L. Arteaga +18 more
TL;DR: The notion that HER2 oligomeric states regulate HER2 signaling is confirmed, also arguing that trastuzumab sensitivity of homodimers may reflect their inability to activate the PI3K (phosphoinositide 3-kinase)/AKT pathway.
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Trastuzumab-Resistant Cells Rely on a HER2-PI3K-FoxO-Survivin Axis and Are Sensitive to PI3K Inhibitors
Anindita Chakrabarty,Neil E. Bhola,Cammie R. Sutton,Ritwik Ghosh,Maria G. Kuba,Bhuvanesh Dave,Jenny C. Chang,Carlos L. Arteaga +7 more
TL;DR: Together, the results suggest that survivin blockade is required for therapeutic responses to trastuzumab and that by combining trASTuzumAB and PI3K inhibitors, CSCs can be reduced within HER2(+) tumors, potentially preventing acquired resistance to anti-HER2 therapy.
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DJ-1 Binds Androgen Receptor Directly and Mediates Its Activity in Hormonally Treated Prostate Cancer Cells
J. Erin Tillman,Jialing Yuan,Guangyu Gu,Ladan Fazli,Ritwik Ghosh,Alex S. Flynt,Martin E. Gleave,Paul S. Rennie,Susan Kasper +8 more
TL;DR: DJ-1 expression did not change with Gleason pattern but increased after androgen deprivation therapy, indicating that it may be involved in the development of androgen independence, and this data provide a novel mechanism where DJ-1-mediated regulation of AR may promote the progression of prostate cancer to androgen independent.
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Human Breast Cancer Cells Harboring a Gatekeeper T798M Mutation in HER2 Overexpress EGFR Ligands and Are Sensitive to Dual Inhibition of EGFR and HER2
Brent N. Rexer,Ritwik Ghosh,Archana Narasanna,Monica V. Estrada,Anindita Chakrabarty,Youngchul Song,Jeffrey A. Engelman,Carlos L. Arteaga +7 more
TL;DR: Simultaneous blockade of HER2 and EGFR should be an effective treatment strategy against HER2 gene–amplified breast cancer cells harboring T798M mutant alleles.
Journal ArticleDOI
Increased expression and differential phosphorylation of stathmin may promote prostate cancer progression.
Ritwik Ghosh,Guangyu Gu,Erin Tillman,Erin Tillman,Jialing Yuan,Yongqing Wang,Ladan Fazli,Paul S. Rennie,Susan Kasper,Susan Kasper +9 more
TL;DR: It is postulate that proteins, which regulate prostate growth also promote prostate cancer (PCa) progression through dysregulation of these functions.