L
Leo Koenderman
Researcher at Utrecht University
Publications - 313
Citations - 19294
Leo Koenderman is an academic researcher from Utrecht University. The author has contributed to research in topics: Eosinophil & Inflammation. The author has an hindex of 67, co-authored 304 publications receiving 17311 citations. Previous affiliations of Leo Koenderman include University of Groningen & University of South Florida.
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Journal ArticleDOI
Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1
TL;DR: It is reported that withdrawal of cytokine results in upregulation of Bimexpression concomitant with induction of the apoptotic program in lymphocytes, and a mechanism by which cytokines promote lymphocyte survival by inhibition of FKHR-L1, preventing Bim expression is proposed.
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In vivo labeling with 2H2O reveals a human neutrophil lifespan of 5.4 days.
Janesh Pillay,Ineke den Braber,Nienke Vrisekoop,Lydia M. Kwast,Rob J. de Boer,José A. M. Borghans,Kiki Tesselaar,Leo Koenderman +7 more
TL;DR: It is shown that in vivo labeling in humans with the use of (2)H(2)O under homeostatic conditions showed an average circulatory neutrophil lifespan of 5.4 days, which is at least 10 times longer than previously reported and might lead to reappraisal of novel neutrophils functions in health and disease.
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A subset of neutrophils in human systemic inflammation inhibits T cell responses through Mac-1
Janesh Pillay,Vera M. Kamp,Els van Hoffen,Tjaakje Visser,Tamar Tak,Jan-Willem J. Lammers,Laurien H. Ulfman,Luke P. H. Leenen,Peter Pickkers,Leo Koenderman +9 more
TL;DR: It is demonstrated that suppression of T cell function can be accomplished by a subset of human neutrophils that can be systemically induced in response to acute inflammation.
Journal ArticleDOI
Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).
Pascale F. Dijkers,René H. Medema,Cornelieke E.G.M. Pals,Lolita Banerji,N.S.B. Thomas,Eric Lam,Boudewijn M.T. Burgering,Jonne A. Raaijmakers,Jan-Willem J. Lammers,Leo Koenderman,P. J. Coffer +10 more
TL;DR: Observations indicate that inhibition of p27KIP1transcription through PI3K-induced FKHR-L1 phosphorylation provides a novel mechanism of regulating cytokine-mediated survival and proliferation.
Journal ArticleDOI
The systemic immune response to trauma: an overview of pathophysiology and treatment.
Janet M. Lord,Mark J. Midwinter,Yen-Fu Chen,Yen-Fu Chen,Antonio Belli,Karim Brohi,Elizabeth J. Kovacs,Leo Koenderman,Paul Kubes,Richard J. Lilford,Richard J. Lilford +10 more
TL;DR: The biological mechanisms and clinical implications of the cascade of events caused by large-scale trauma that leads to multiorgan failure and death, despite the stemming of blood loss are examined.