Robby Zachariah Tom

TL;DR: It is shown that LPL-governed microglial immunometabolism is essential to maintain microglia function upon exposure to an HCHF diet, and lack of such an adaptive immunometabolic response has detrimental effects on CNS regulation of energy metabolism.

TL;DR: Findings suggest potential opportunities for employing combination treatments that comprise parallel MC4R and GLP‐1R agonism for the treatment of obesity and diabetes and increases expression of each receptor, indicative of minimized receptor desensitization.

TL;DR: The role of leptin signaling in microglia in systemic metabolic control is found to be important for microglial function and a correct formation of the hypothalamic neuronal circuit regulating metabolism.

TL;DR: This study demonstrates MSOT as an efficient imaging tool for lipid visualization in preclinical studies, particularly for the assessment of NAFLD.

TL;DR: In this article, the authors investigated the potential of multispectral optoacoustic tomography (MSOT) as a novel modality to noninvasively visualize lipids in laboratory mice around the 930nm spectral range.