N
Niklas Grassl
Researcher at Max Planck Society
Publications - 8
Citations - 701
Niklas Grassl is an academic researcher from Max Planck Society. The author has contributed to research in topics: Proteome & Stromal cell. The author has an hindex of 6, co-authored 8 publications receiving 499 citations. Previous affiliations of Niklas Grassl include Helmholtz Zentrum München & Technische Universität München.
Papers
More filters
Journal ArticleDOI
Parallel Accumulation–Serial Fragmentation (PASEF): Multiplying Sequencing Speed and Sensitivity by Synchronized Scans in a Trapped Ion Mobility Device
Florian Meier,Scarlet Beck,Niklas Grassl,Markus Lubeck,Melvin A. Park,Oliver Raether,Matthias Mann +6 more
TL;DR: In this paper, a parallel accumulation-serial fragmentation (PASEF) method was proposed to enable hundreds of MS/MS events per second at full sensitivity for shotgun proteomics.
Journal ArticleDOI
Proteomics reveals the effects of sustained weight loss on the human plasma proteome.
Philipp E. Geyer,Philipp E. Geyer,Nicolai J. Wewer Albrechtsen,Stefka Tyanova,Niklas Grassl,Eva W. Iepsen,Julie R. Lundgren,Sten Madsbad,Jens J. Holst,Signe S. Torekov,Matthias Mann,Matthias Mann +11 more
TL;DR: The plasma proteomes of a cohort of 43 obese individuals that had undergone 8 weeks of 12% body weight loss followed by a year of weight maintenance are investigated and plasma proteome profiling broadly evaluates and monitors intervention in metabolic diseases.
Journal ArticleDOI
Ultra-deep and quantitative saliva proteome reveals dynamics of the oral microbiome
Niklas Grassl,Nils A. Kulak,Garwin Pichler,Philipp E. Geyer,Philipp E. Geyer,Jette Jung,Soeren Schubert,Pavel Sinitcyn,Juergen Cox,Matthias Mann,Matthias Mann +10 more
TL;DR: Rapid shotgun and robust technology can now simultaneously characterize the human and microbiome contributions to the proteome of a body fluid and is therefore a valuable complement to genomic studies.
Journal ArticleDOI
Dual melanocortin‐4 receptor and GLP‐1 receptor agonism amplifies metabolic benefits in diet‐induced obese mice
Christoffer Clemmensen,Christoffer Clemmensen,Brian Finan,Brian Finan,Katrin Fischer,Katrin Fischer,Robby Zachariah Tom,Beata Legutko,Beata Legutko,Laura Sehrer,Laura Sehrer,Daniela Heine,Daniela Heine,Niklas Grassl,Niklas Grassl,Carola W. Meyer,Carola W. Meyer,Bart Henderson,Susanna M. Hofmann,Matthias H. Tschöp,Matthias H. Tschöp,Lex H.T. Van der Ploeg,Timo D. Müller,Timo D. Müller +23 more
TL;DR: Findings suggest potential opportunities for employing combination treatments that comprise parallel MC4R and GLP‐1R agonism for the treatment of obesity and diabetes and increases expression of each receptor, indicative of minimized receptor desensitization.
Journal ArticleDOI
A Web-Based Survey Assessing the Attitudes of Health Care Professionals in Germany Toward the Use of Telemedicine in Pregnancy Monitoring: Cross-Sectional Study.
Niklas Grassl,Juliane Nees,Katharina Schramm,Julia Spratte,Christof Sohn,Timm Cornelius Schott,Sarah Schott +6 more
TL;DR: An ambivalent attitude toward the use of telemedicine among health care professionals in obstetrics in Germany is revealed, particularly young physicians recognize the potential of apps in patient care and would like to use such technology in pregnancy monitoring.