R
Robert A. Brooksbank
Researcher at Wellcome Trust Sanger Institute
Publications - 2
Citations - 747
Robert A. Brooksbank is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: Virus & Hypogammaglobulinemia. The author has an hindex of 2, co-authored 2 publications receiving 723 citations.
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Host response to EBV infection in X-linked lymphoproliferative disease results from mutations in an SH2-domain encoding gene
Alison J. Coffey,Robert A. Brooksbank,Oliver Brandau,Toshitaka Oohashi,Gareth R. Howell,Jacqueline M. Bye,Anthony P. Cahn,Anthony P. Cahn,Jillian Durham,Paul Heath,Paul Wray,Rebecca Pavitt,Jane Wilkinson,Margaret A. Leversha,Elizabeth J. Huckle,Charles Shaw-Smith,Andrew Dunham,Susan Rhodes,Volker Schuster,Giovanni Porta,Luo Yin,Paola Serafini,Bakary S. Sylla,Massimo Zollo,Brunella Franco,Alessandra Bolino,Marco Seri,Arpad Lanyi,Jack R. Davis,David Webster,Ann Harris,Gilbert M. Lenoir,Genevieve de St Basile,Alison Jones,Bernd H. Behloradsky,Helene Achatz,Jan Murken,Reinhard Fässler,Janos Sumegi,Giovanni Romeo,M. Vaudin,Mark T. Ross,Alfons Meindl,David R. Bentley +43 more
TL;DR: A gene, SH2D1A, is identified that is mutated in XLP patients and encodes a novel protein composed of a single SH2 domain that is expressed in many tissues involved in the immune system.
Journal ArticleDOI
A new candidate region for the positional cloning of the XLP gene.
Alessandra Bolino,Luo Yin,Marco Seri,Roberto Cusano,Roberta Cinti,Alison J. Coffey,Robert A. Brooksbank,Gareth R. Howell,David Bentley,Jack R. Davis,Arpad Lanyi,Doli Huang,Markus Stark,Martina Creaven,Lise Bjørkhaug,Fabrice Heitzmann,Jérôme Lamartine,Simona Gaudi,Bakary S. Sylla,Gilbert M. Lenoir,Elio Castagnola,Raffaella Giacchino,Giovanni Porta,Giovanni Porta,Brunella Franco,Massimo Zollo,Janos Sumegi,Giovanni Romeo,Giovanni Romeo +28 more
TL;DR: Two recombination events in a North American family and a new microdeletion (XLP-G in an Italian family indicate that the XLP gene maps in the interval between DXS1001 and DXS8057, approximately 800 kb centromeric to the previously reported familial micro deletion XLP-D.