R
Raffaella Giacchino
Researcher at Istituto Giannina Gaslini
Publications - 101
Citations - 3555
Raffaella Giacchino is an academic researcher from Istituto Giannina Gaslini. The author has contributed to research in topics: Hepatitis C virus & Hepatitis C. The author has an hindex of 32, co-authored 101 publications receiving 3438 citations. Previous affiliations of Raffaella Giacchino include Boston Children's Hospital & University of Naples Federico II.
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Journal ArticleDOI
Long-Term Course of Chronic Hepatitis C in Children: From Viral Clearance to End-Stage Liver Disease
Flavia Bortolotti,Gabriella Verucchi,Calogero Cammà,Giuseppe Cabibbo,Lucia Zancan,Giuseppe Indolfi,Raffaella Giacchino,Matilde Marcellini,Maria Grazia Marazzi,Cristiana Barbera,Giuseppe Maggiore,Pietro Vajro,S. Bartolacci,Fiorella Balli,Anna Maccabruni,Maria Guido +15 more
TL;DR: Over the course of a decade, few children with chronic HCV infection cleared viremia spontaneously, and those who did were more likely to have genotype 3, leading to end-stage liver disease in a small subgroup characterized by perinatal exposure, maternal drug use, and infection with HCV genotype 1a.
Journal ArticleDOI
Liposomal amphotericin B (AmBisome) in Mediterranean visceral leishmaniasis: a multi-centre trial.
Robert N. Davidson,L. di Martino,L Gradoni,Raffaella Giacchino,R. Russo,Giovanni Battista Gaeta,R. Pempinello,S. Scott,Francesco Raimondi,Antonio Cascio,Tullio Prestileo,L. Caldeira,Robert J. Wilkinson,A. D. M. Bryceson +13 more
TL;DR: Thirty-one patients with visceral leishmaniasis (VL) caused by Leishmania infantum received liposomal amphotericin B (AmBisome) in a multi-centre study and were cured without significant adverse events and without relapse during 12-24 months of follow-up.
Journal ArticleDOI
Chronic hepatitis C virus infection in childhood: clinical patterns and evolution in 224 white children.
Paloma Jara,Massimo Resti,Loreto Hierro,Raffaella Giacchino,Cristiana Barbera,Lucia Zancan,Carlo Crivellaro,Etienne Sokal,Chiara Azzari,Maria Guido,Flavia Bortolotti +10 more
TL;DR: Pediatric HCV infection is usually mild, but few patients, especially those who are perinatally infected, clear viremia in the medium-term follow-up, and the higher rates of fibrosis observed in older patients suggest the possibility of an insidious progression of HCV-associated liver disease.
Journal ArticleDOI
Short-course treatment of visceral leishmaniasis with liposomal amphotericin B (AmBisome)
Robert N. Davidson,L. di Martino,L Gradoni,Raffaella Giacchino,Giovanni Battista Gaeta,R. Pempinello,S. Scotti,Antonio Cascio,Elio Castagnola,Angela Maisto,Marina Gramiccia,D. di Caprio,Robert J. Wilkinson,A. D. M. Bryceson +13 more
TL;DR: Liposomal amphotericin B (AmBisome) was administered to 88 immunocompetent patients (56 children) with visceral leishmaniasis (VL) caused by Leishmania infantum and four children who were not cured received 3 mg/kg for 10 days; none had further relapses.
Journal ArticleDOI
Clinical features and progression of perinatally acquired hepatitis C virus infection.
Massimo Resti,Paloma Jara,Loreto Hierro,Chiara Azzari,Raffaella Giacchino,Giovanna Zuin,Lucia Zancan,Sabrina Pedditzi,Flavia Bortolotti +8 more
TL;DR: The early stage of acquired perinatally HCV infection is characterized by a wide range of ALT abnormalities, suggesting the interaction of multiple host and virus factors, and high ALT levels at onset seem to offer greater opportunity of biochemical remission and loss of viremia during follow‐up.