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Robert A. Campbell
Researcher at University of Utah
Publications - 105
Citations - 5771
Robert A. Campbell is an academic researcher from University of Utah. The author has contributed to research in topics: Platelet & Platelet activation. The author has an hindex of 27, co-authored 87 publications receiving 3520 citations. Previous affiliations of Robert A. Campbell include University of North Carolina at Chapel Hill.
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Journal ArticleDOI
Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome.
Elizabeth A. Middleton,Xue-Yan He,Frederik Denorme,Robert A. Campbell,David Ng,Steven P. Salvatore,Steven P. Salvatore,Maria Mostyka,Amelia Baxter-Stoltzfus,Alain C. Borczuk,Alain C. Borczuk,Massimo Loda,Massimo Loda,Mark J. Cody,Bhanu Kanth Manne,Irina Portier,Estelle S. Harris,Aaron C. Petrey,Ellen J. Beswick,Aleah F. Caulin,Anthony J. Iovino,Lisa M. Abegglen,Andrew S. Weyrich,Matthew T. Rondina,Mikala Egeblad,Joshua D. Schiffman,Christian C. Yost +26 more
TL;DR: NETs triggering immunothrombosis may, in part, explain the prothrombotic clinical presentations in COVID-19, and NETs may represent targets for therapeutic intervention.
Journal ArticleDOI
Platelet gene expression and function in patients with COVID-19.
Bhanu Kanth Manne,Frederik Denorme,Elizabeth A. Middleton,Irina Portier,Jesse W. Rowley,Chris Stubben,Aaron C. Petrey,Neal D. Tolley,Li Guo,Mark J. Cody,Andrew S. Weyrich,Christian C. Yost,Matthew T. Rondina,Robert A. Campbell +13 more
TL;DR: It is demonstrated that SARS-CoV-2 infection is associated with platelet hyperreactivity, which may contribute to COVID-19 pathophysiology.
Journal ArticleDOI
Thrombin Generation, Fibrin Clot Formation and Hemostasis
TL;DR: Cl clot formation in vivo occurs in an environment in which the concentration of free thrombin changes over the reaction course, and changes depend on local cellular properties and available concentrations of pro- and anti-coagulants.
Journal ArticleDOI
Platelets: versatile effector cells in hemostasis, inflammation, and the immune continuum
TL;DR: The experimental findings and evidence for physiologic immune functions include previously unrecognized biologic characteristics of Platelets and are paralleled by new evidence for unique roles of platelets in inflammatory, immune, and thrombotic diseases.
Journal ArticleDOI
Novel anti-bacterial activities of β-defensin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation.
Bjoern F. Kraemer,Robert A. Campbell,Hansjörg Schwertz,Mark J. Cody,Zechariah Franks,Neal D. Tolley,Walter H. A. Kahr,Stephan Lindemann,Peter Seizer,Christian C. Yost,Guy A. Zimmerman,Andrew S. Weyrich +11 more
TL;DR: Data demonstrate that hBD-1 is a previously-unrecognized component of platelets that displays classic antimicrobial activity and, in addition, signals PMNs to extrude DNA lattices that capture and kill bacteria.