S
Stephan Lindemann
Researcher at University of Tübingen
Publications - 71
Citations - 5361
Stephan Lindemann is an academic researcher from University of Tübingen. The author has contributed to research in topics: Platelet & Platelet activation. The author has an hindex of 35, co-authored 70 publications receiving 4971 citations. Previous affiliations of Stephan Lindemann include University of Utah & University of Mainz.
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Journal ArticleDOI
Activated platelets mediate inflammatory signaling by regulated interleukin 1β synthesis
Stephan Lindemann,Neal D. Tolley,Dan A. Dixon,Thomas M. McIntyre,Stephen M. Prescott,Guy A. Zimmerman,Andrew S. Weyrich +6 more
TL;DR: Inhibition of β3 integrin engagement markedly attenuated the synthesis of IL-1β, identifying a new link between the coagulation and inflammatory cascades, and suggesting that antithrombotic therapies may also have novel antiinflammatory effects.
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Escaping the Nuclear Confines: Signal-Dependent Pre-mRNA Splicing in Anucleate Platelets
Melvin M. Denis,Neal D. Tolley,Michaeline Bunting,Hansjörg Schwertz,Huimiao Jiang,Stephan Lindemann,Christian C. Yost,Frederick J. Rubner,Kurt H. Albertine,Kathryn J. Swoboda,Carolyn M. Fratto,Emilysa Tolley,Larry W. Kraiss,Thomas M. McIntyre,Guy A. Zimmerman,Andrew S. Weyrich +15 more
TL;DR: Signal-dependent splicing is a novel function of platelets that demonstrates remarkable specialization in the regulatory repertoire of this anucleate cell and suggests previously unrecognized diversity regarding the functional roles of the spliceosome in eukaryotic cells.
Journal ArticleDOI
The evolving role of platelets in inflammation
TL;DR: The evolutionary paths, traditional roles, and previously unrecognized biological capacities of platelets that interface thrombosis with inflammation are reviewed and new roles in inflammatory diseases are identified.
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Platelet-Derived Stromal Cell–Derived Factor-1 Regulates Adhesion and Promotes Differentiation of Human CD34+ Cells to Endothelial Progenitor Cells
Konstantinos Stellos,Harald F. Langer,Karin Daub,Tanja Schoenberger,Alexandra Gauss,Tobias Geisler,Boris Bigalke,Iris I. Mueller,Michael Schumm,Iris Schaefer,Peter Seizer,Bjoern F. Kraemer,Dorothea Siegel-Axel,Andreas E. May,Stephan Lindemann,Meinrad Gawaz +15 more
TL;DR: Findings imply that platelet-derived SDF-1 regulates adhesion of stem cells in vitro and in vivo and promotes differentiation of CD34+ cells to endothelial progenitor cells.
Journal ArticleDOI
Novel anti-bacterial activities of β-defensin 1 in human platelets: suppression of pathogen growth and signaling of neutrophil extracellular trap formation.
Bjoern F. Kraemer,Robert A. Campbell,Hansjörg Schwertz,Mark J. Cody,Zechariah Franks,Neal D. Tolley,Walter H. A. Kahr,Stephan Lindemann,Peter Seizer,Christian C. Yost,Guy A. Zimmerman,Andrew S. Weyrich +11 more
TL;DR: Data demonstrate that hBD-1 is a previously-unrecognized component of platelets that displays classic antimicrobial activity and, in addition, signals PMNs to extrude DNA lattices that capture and kill bacteria.