J
Joshua D. Schiffman
Researcher at Huntsman Cancer Institute
Publications - 208
Citations - 9900
Joshua D. Schiffman is an academic researcher from Huntsman Cancer Institute. The author has contributed to research in topics: Cancer & Population. The author has an hindex of 41, co-authored 189 publications receiving 7606 citations. Previous affiliations of Joshua D. Schiffman include Stanford University & Rhode Island Hospital.
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Journal ArticleDOI
Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome.
Elizabeth A. Middleton,Xue-Yan He,Frederik Denorme,Robert A. Campbell,David Ng,Steven P. Salvatore,Steven P. Salvatore,Maria Mostyka,Amelia Baxter-Stoltzfus,Alain C. Borczuk,Alain C. Borczuk,Massimo Loda,Massimo Loda,Mark J. Cody,Bhanu Kanth Manne,Irina Portier,Estelle S. Harris,Aaron C. Petrey,Ellen J. Beswick,Aleah F. Caulin,Anthony J. Iovino,Lisa M. Abegglen,Andrew S. Weyrich,Matthew T. Rondina,Mikala Egeblad,Joshua D. Schiffman,Christian C. Yost +26 more
TL;DR: NETs triggering immunothrombosis may, in part, explain the prothrombotic clinical presentations in COVID-19, and NETs may represent targets for therapeutic intervention.
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SDH5, a Gene Required for Flavination of Succinate Dehydrogenase, Is Mutated in Paraganglioma
Huai Xiang Hao,Oleh Khalimonchuk,Margit Schraders,Noah Dephoure,Jean-Pierre Bayley,Henricus P. M. Kunst,Peter Devilee,Cor W. R. J. Cremers,Joshua D. Schiffman,Brandon G. Bentz,Steven P. Gygi,Dennis R. Winge,Hannie Kremer,Jared Rutter +13 more
TL;DR: A combination of bioinformatics, yeast genetics, biochemistry, and human genetics was used to show that a previously uncharacterized mitochondrial protein (Sdh5) is required for the activity of respiratory complex II, leading to the discovery of a human tumor susceptibility gene.
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The Epidemiology of Sarcoma
TL;DR: The limited studies identified demonstrate significant relationships with sarcoma risk, but many of these results now require further validation on larger populations and will be important to assess in future studies.
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Potential Mechanisms for Cancer Resistance in Elephants and Comparative Cellular Response to DNA Damage in Humans
Lisa M. Abegglen,Aleah F. Caulin,Ashley Chan,Kristy Lee,Rosann Robinson,Michael S. Campbell,Wendy K. Kiso,Dennis L. Schmitt,Peter J. Waddell,Srividya Bhaskara,Shane T. Jensen,Carlo C. Maley,Joshua D. Schiffman +12 more
TL;DR: Elephants appeared to have a lower-than-expected rate of cancer, potentially related to multiple copies of TP53, and could represent an evolutionary-based approach for understanding mechanisms related to cancer suppression.
Journal ArticleDOI
Succinate dehydrogenase - Assembly, regulation and role in human disease.
TL;DR: Under this heightened scrutiny, the succinate dehydrogenase complex has proven to be a fascinating machine, whose regulation and assembly requires additional factors that are beginning to be discovered.