R
Robert Booher
Researcher at Cold Spring Harbor Laboratory
Publications - 12
Citations - 3084
Robert Booher is an academic researcher from Cold Spring Harbor Laboratory. The author has contributed to research in topics: Cyclin-dependent kinase 1 & Mitosis. The author has an hindex of 10, co-authored 11 publications receiving 3040 citations. Previous affiliations of Robert Booher include University of California, San Francisco.
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Journal ArticleDOI
cdc25 is a specific tyrosine phosphatase that directly activates p34cdc2
TL;DR: It is found that the cdc25 sequence shows weak but significant homology to a phylogenetically diverse group of protein tyrosine phosphatases, and is a specific protein phosphatase that dephosphorylates tyrosines and possibly threonine residues on p34cdc2 and regulates MPF activation.
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mik1 and wee1 cooperate in the inhibitory tyrosine phosphorylation of cdc2
Karen Lundgren,Nancy C. Walworth,Robert Booher,Marlene Dembski,Marc W. Kirschner,David Beach +5 more
TL;DR: It is shown here that a related 66 kd kinase, called mik1, acts redundantly with wee1 in the negative regulation of cdc2 in S, both in strains undergoing mitotic lethality and in those that are viable owing to a compensating mutation within cDC2.
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The fission yeast cdc2/cdc13/suc1 protein kinase: Regulation of catalytic activity and nuclear localization
TL;DR: Observations suggest that the cdc13+-encoded cyclin acts to regulate both the catalytic properties and the localization of the protein kinase of which it is a subunit.
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Properties of Saccharomyces cerevisiae wee1 and its differential regulation of p34CDC28 in response to G1 and G2 cyclins.
TL;DR: Results suggest that specific cyclin subunits target p34CDC28 for distinct regulatory controls which may be important for ensuring proper p34 CDC28 function during the cell cycle.
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Involvement of cdc13+ in mitotic control in Schizosaccharomyces pombe: possible interaction of the gene product with microtubules.
Robert Booher,David Beach +1 more
TL;DR: The observation that cDC13‐117 mutant strains were found to be hypersensitive to the tubulin inhibitor thiabendazole suggests that the cdc13+ gene product, which is required for mitotic initiation, may interact with microtubules.