R
Robert G. Phelps
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 221
Citations - 7507
Robert G. Phelps is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Biopsy & Pseudoxanthoma elasticum. The author has an hindex of 44, co-authored 215 publications receiving 7057 citations. Previous affiliations of Robert G. Phelps include George Washington University & University Medical Center New Orleans.
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Journal ArticleDOI
A phase 1/2 clinical trial of enzyme replacement in fabry disease: pharmacokinetic, substrate clearance, and safety studies.
Christine M. Eng,Maryam Banikazemi,Ronald E. Gordon,Martin E. Goldman,Robert G. Phelps,Leona Kim,Alan Gass,Jonathan A. Winston,Steven Dikman,John T. Fallon,Scott E. Brodie,Charles B. Stacy,Davendra Mehta,Rosaleen Parsons,Karen I. Norton,Michael O'Callaghan,Robert J. Desnick +16 more
TL;DR: A single-center, open-label, dose-ranging study of r-halphaGalA treatment in 15 patients, each of whom received five infusions at one of five dose regimens provides the basis for a phase 3 trial of enzyme-replacement therapy for Fabry disease.
Journal Article
BRAF Oncogenic Mutations Correlate with Progression rather than Initiation of Human Melanoma
Jianli Dong,Robert G. Phelps,Rui Qiao,Shen Yao,Outhiriaradjou Benard,Ze'ev Ronai,Stuart A. Aaronson +6 more
TL;DR: The findings imply that BRAF mutations cannot be involved in the initiation of the great majority of melanomas but instead reflect a progression event with important prognostic implications in the transition from the greatmajority of RGP melanomas to VGP and/or metastatic melanoma.
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Comparison of two density gradient centrifugation systems for the enrichment of disseminated tumor cells in blood.
Robert D. Rosenberg,Ralf Gertler,Jan Friederichs,K. Fuehrer,M. Dahm,Robert G. Phelps,Stefan Thorban,Hjalmar Nekarda,J. R. Siewert +8 more
TL;DR: Processing blood from tumor patients with OncoQuick increased the chance of detecting circulating tumor cells and simplified immunocytochemical evaluation by reducing the number of cytospins and increasing the tumor cell density.
Journal ArticleDOI
Smoking cessation after successful treatment of small-cell lung cancer is associated with fewer smoking-related second primary cancers.
Gary Richardson,M A Tucker,David Venzon,R. I. Linnoila,Robert G. Phelps,John C. Phares,Margaret Edison,Daniel C. Ihde,Bruce E. Johnson +8 more
TL;DR: To estimate the risk for second primary cancers in survivors of small-cell lung cancer, all patients with this malignancy who remained disease free for 2 years after the initiation of therapy at the National Cancer Institute were evaluated.
Journal Article
High frequency of somatically acquired p53 mutations in small-cell lung cancer cell lines and tumors.
Domenico D'Amico,David Carbone,Tetsuya Mitsudomi,Marion M. Nau,J. Fedorko,E. Russell,Bruce E. Johnson,Dorothy L. Buchhagen,S Bodner,Robert G. Phelps +9 more
TL;DR: P53 mutations are found in SCLC with high frequency; p53 mutations in a significant fraction of cases generate cDNAs with nonsense or splicing mutations; and to date, these mutations have all been somatically acquired events.