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Robert Gentleman
Researcher at Genentech
Publications - 140
Citations - 53506
Robert Gentleman is an academic researcher from Genentech. The author has contributed to research in topics: Bioconductor & Gene expression profiling. The author has an hindex of 52, co-authored 139 publications receiving 48510 citations. Previous affiliations of Robert Gentleman include Harvard University & Brigham and Women's Hospital.
Papers
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gplots: Various R Programming Tools for Plotting Data
Gregory R. Warnes,Ben Bolker,L. Bonebakker,Robert Gentleman,Wha Liaw,T. Lumley,M Maechler,A. Magnusson,S. Moeller,Michael L. Schwartz,B Venables,Wolfgang Huber,Andy Liaw,R. Gregory,BB Warnes,Lodewijk Bonebakker,Robert Gentleman,Wolfgang Huber Andy Liaw,Thomas Lumley,Martin Maechler,Arni Magnusson,Steffen Moeller,Marc Schwartz,Bill Venables +23 more
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A Model-Based Background Adjustment for Oligonucleotide Expression Arrays
TL;DR: The default ad hoc adjustment, provided as part of the Affymetrix system, can be improved through the use of estimators derived from a statistical model that uses probe sequence information, which greatly improves the performance of the technology in various practical applications.
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Using GOstats to test gene lists for GO term association
Seth Falcon,Robert Gentleman +1 more
TL;DR: The capabilities of GOstats, a Bioconductor package written in R, that allows users to test GO terms for over or under-representation using either a classical hypergeometric test or a conditionalhypergeometric that uses the relationships among GO terms to decorrelate the results are discussed.
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Recurrent R-spondin fusions in colon cancer
Somasekar Seshagiri,Eric Stawiski,Steffen Durinck,Zora Modrusan,Elaine E. Storm,Caitlin B. Conboy,Subhra Chaudhuri,Yinghui Guan,Vasantharajan Janakiraman,Bijay S. Jaiswal,Joseph Guillory,Connie Ha,Gerrit J. P. Dijkgraaf,Jeremy Stinson,Florian Gnad,Melanie A. Huntley,Jeremiah D. Degenhardt,Peter M. Haverty,Richard Bourgon,Weiru Wang,Hartmut Koeppen,Robert Gentleman,Timothy K. Starr,Zemin Zhang,David A. Largaespada,Thomas D. Wu,Frederic J. de Sauvage +26 more
TL;DR: The R-spondin gene fusions, several new recurrent mutations in the Wnt pathway gene TCF7L2, chromatin-remodelling genes such as TET2 and TET3 and receptor tyrosine kinases including ERBB3 are identified and shown to be capable of potentiating Wnt signalling.
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Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer
Charles M. Rudin,Steffen Durinck,Eric Stawiski,John T. Poirier,Zora Modrusan,David S. Shames,Emily Bergbower,Yinghui Guan,James Shin,Joseph Guillory,Celina Sanchez Rivers,Catherine K. Foo,Deepali Bhatt,Jeremy Stinson,Florian Gnad,Peter M. Haverty,Robert Gentleman,Subhra Chaudhuri,Vasantharajan Janakiraman,Bijay S. Jaiswal,Chaitali Parikh,Wenlin Yuan,Zemin Zhang,Hartmut Koeppen,Thomas D. Wu,Howard M. Stern,Robert L. Yauch,Kenneth E. Huffman,Diego D Paskulin,Peter B. Illei,Marileila Varella-Garcia,Adi F. Gazdar,Frederic J. de Sauvage,Richard Bourgon,John D. Minna,Malcolm V. Brock,Somasekar Seshagiri +36 more
TL;DR: Exome, transcriptome and copy-number alteration data are obtained from approximately 53 samples consisting of 36 primary human SCLC and normal tissue pairs and 17 matched SCLCs and lymphoblastoid cell lines to identify several potential targets for therapeutic intervention.