R
Robert Huber
Researcher at Technische Universität München
Publications - 742
Citations - 76282
Robert Huber is an academic researcher from Technische Universität München. The author has contributed to research in topics: Active site & Protein structure. The author has an hindex of 139, co-authored 671 publications receiving 73557 citations. Previous affiliations of Robert Huber include Munich University of Applied Sciences & Russian Academy of Sciences.
Papers
More filters
Journal ArticleDOI
Structural basis for Ca2+-independence and activation by homodimerization of tomato subtilase 3
Christian Ottmann,Rolf Rose,Franziska Huttenlocher,Anna Cedzich,Patrick Hauske,Markus Kaiser,Robert Huber,Andreas Schaller +7 more
TL;DR: This work reports the first structure of a plant subtilase, SBT3 from tomato, in the active apo form and complexed with a chloromethylketone (cmk) inhibitor and presents the first structural evidence for an explicit function of PA domains in proteases revealing a vital role in the homo-dimerization ofSBT3 and in enzyme activation.
Book ChapterDOI
Structure quality and target parameters
Richard A. Engh,Robert Huber +1 more
TL;DR: In this paper, a set of bond and angle target parameters derived from small-molecule structures in the Cambridge Structural Database and their application to the refinement of protein structure models are discussed.
Journal ArticleDOI
A dissimilatory sirohaem-sulfite-reductase-type protein from the hyperthermophilic archaeon Pyrobaculum islandicum.
Michael Molitor,Christiane Dahl,Ilka M. Molitor,Ulrike Schäfer,Norbert Speich,Robert Huber,Rainer Deutzmann,Hans G. Trüper +7 more
TL;DR: Phylogenetic analyses indicate a common protogenotic origin of the P. islandicum protein and the dissimilatory sulfite reductases from sulfate-reducing and sulfide-oxidizing prokaryotes most probably evolved into three independent lineages prior to divergence of archaea and bacteria.
Journal ArticleDOI
The substrate translocation channel of the proteasome.
Alwin Köhler,Monica Bajorek,Michael Groll,Luis Moroder,David T. Rubin,Robert Huber,Michael H. Glickman,Daniel Finley +7 more
TL;DR: These results identify a specific mechanism for allosteric regulation of the CP by the RP, and show that open-channel mutations in CP subunits suppress the closed-channel phenotype of an rpt2 mutant.
Journal ArticleDOI
Crystal structure of MunI restriction endonuclease in complex with cognate DNA at 1.7 Å resolution
TL;DR: The MunI restriction enzyme recognizes the palindromic hexanucleotide sequence C/AATTG and the crystal structure of its active site mutant D83A bound to cognate DNA has been determined at 1.7 Å resolution.