R
Robert Huber
Researcher at Technische Universität München
Publications - 742
Citations - 76282
Robert Huber is an academic researcher from Technische Universität München. The author has contributed to research in topics: Active site & Protein structure. The author has an hindex of 139, co-authored 671 publications receiving 73557 citations. Previous affiliations of Robert Huber include Munich University of Applied Sciences & Russian Academy of Sciences.
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Biochemical characterization of Bacillus subtilis type II isopentenyl diphosphate isomerase, and phylogenetic distribution of isoprenoid biosynthesis pathways.
Ralf Laupitz,Stefan Hecht,Sabine Amslinger,Ferdinand Zepeck,Johannes Kaiser,Gerald Richter,Nicholas Schramek,Stefan Steinbacher,Robert Huber,Duilio Arigoni,Adelbert Bacher,Wolfgang Eisenreich,Felix Rohdich +12 more
TL;DR: Type II isomerase is essential in some important human pathogens including Staphylococcus aureus and Enterococcus faecalis where it may represent a novel target for anti-infective therapy and in 283 completed and unfinished prokaryotic genomes revealed 10 different classes.
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Crystal Structure of the Dinuclear Zinc Aminopeptidase PepV from Lactobacillus delbrueckii Unravels Its Preference for Dipeptides
Daniela Jozic,Gleb Bourenkow,Hans D. Bartunik,Henning Scholze,Vincent Dive,Bernhard Henrich,Robert Huber,Wolfram Bode,Klaus Maskos +8 more
TL;DR: PepV from Lactobacillus delbrueckii, a dinuclear zinc peptidase, has been characterized as an unspecific amino dipeptidase as well as a "catalytic domain" and a "lid domain" which together form an internal active site cavity that traps the inhibitor.
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Crystal structure of cystalysin from Treponema denticola: a pyridoxal 5′-phosphate-dependent protein acting as a haemolytic enzyme
TL;DR: Analysis of the cystalysin–L‐aminoethoxyvinylglycine (AVG) complex revealed a ‘dead end’ ketimine PLP derivative, resulting in a total loss of enzyme activity, which may provide the chemical basis for rational drug design.
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Nickel serves as a substrate recognition motif for the endopeptidase involved in hydrogenase maturation.
Ekaterini Theodoratou,Athanasios Paschos,Axel Magalon,Erich Fritsche,Robert Huber,August Böck +5 more
TL;DR: It is concluded that the endopeptidase uses the metal in the large subunit of [NiFe]-hydrogenases as a recognition motif.
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Crystal structure of the cystine C-S lyase from Synechocystis: Stabilization of cysteine persulfide for FeS cluster biosynthesis
TL;DR: Binding and stabilization of the cysteine persulfide represent an alternative to the generation of a protein-bound Persulfide by NifS-like proteins and point to the general importance of persulfidic compounds for FeS cluster assembly.