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Robert J. Fenster
Researcher at Harvard University
Publications - 19
Citations - 1364
Robert J. Fenster is an academic researcher from Harvard University. The author has contributed to research in topics: Gene expression & Cell sorting. The author has an hindex of 10, co-authored 17 publications receiving 993 citations. Previous affiliations of Robert J. Fenster include Washington University in St. Louis & McLean Hospital.
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Cell type–specific mRNA purification by translating ribosome affinity purification (TRAP)
TL;DR: This protocol provides a step-by-step guide to implement the TRAP methodology, which takes 2 d to complete once all materials are in hand and bypasses the need for tissue fixation or single-cell suspensions and reports on mRNAs in the entire cell body.
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Impaired hippocampal-dependent learning and functional abnormalities in the hippocampus in mice lacking serotonin(1A) receptors.
Zoltán Sarnyai,Etienne Sibille,Constantine Pavlides,Robert J. Fenster,Bruce S. McEwen,Miklós Tóth +5 more
TL;DR: It is demonstrated that 5-HT(1A) receptors are required for maintaining normal hippocampal functions and implicate a role for the 5- HT( 1A) receptor in hippocampal-related symptoms, such as cognitive disturbances, in stress-related disorders.
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Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man
TL;DR: This work describes the current understanding of the circuit dysfunction that underlies the symptoms of post-traumatic stress disorder and provides further insights into the mechanisms of risk and resilience.
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Cell Type-Specific Transcriptomics Reveals that Mutant Huntingtin Leads to Mitochondrial RNA Release and Neuronal Innate Immune Activation
Hyeseung Lee,Robert J. Fenster,S. Sebastian Pineda,Whitney S. Gibbs,Shahin Mohammadi,Jose Davila-Velderrain,Jose Davila-Velderrain,Francisco J. Garcia,Martine Therrien,Martine Therrien,Hailey S. Novis,Fan Gao,Hilary Wilkinson,Thomas F. Vogt,Manolis Kellis,Manolis Kellis,Matthew J. LaVoie,Myriam Heiman,Myriam Heiman,Myriam Heiman +19 more
TL;DR: It is revealed that the activation of innate immune signaling in the most vulnerable HD neurons provides a novel framework to understand the basis of mHTT toxicity and raises new therapeutic opportunities.
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Molecular adaptations of striatal spiny projection neurons during levodopa-induced dyskinesia
Myriam Heiman,Adrian Heilbut,Veronica Francardo,Ruth Kulicke,Robert J. Fenster,Eric D. Kolaczyk,Eric D. Kolaczyk,Jill P. Mesirov,Dalton James Surmeier,M. Angela Cenci,Paul Greengard +10 more
TL;DR: Different cell-type–specific gene-expression changes that occur in subclasses of SPNs upon induction of a parkinsonian lesion followed by chronic levodopa treatment are identified, providing potential targets for antidyskinetic treatments in Parkinson's disease.