Dalton James Surmeier

TL;DR: This multiple‐author article provides a historical state‐of‐the‐art account of what has been achieved, the current situation, and how to progress toward resolving Parkinson's disease.

TL;DR: Recurrent collateral connections between MSNs are not random but rather differentially couple D1 and D2 MSNs, potentially contributing to pathological alterations in MSN activity patterns and psychomotor symptoms in Parkinson's disease models.

TL;DR: Differences in release probability and short-term synaptic plasticity suggest that corticostriatal and thalamostRIatal projection systems code information in temporally distinct ways, constraining how they regulate striatal circuitry.

TL;DR: Analysis revealed that isradipine produced a dose-dependent sparing of DA fibers and cell bodies at concentrations achievable in humans, suggesting that is Radipine is a potentially viable neuroprotective agent for PD.

TL;DR: The hypothesis that the primary factor driving neurodegenerative changes in PD is the metabolic stress created by Ca²⁺ entry is examined, particularly in the face of genetic or environmental factors that compromise oxidative defenses or proteostatic competence.