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Robert J. Walker
Researcher at University of Southampton
Publications - 282
Citations - 6284
Robert J. Walker is an academic researcher from University of Southampton. The author has contributed to research in topics: Acetylcholine & Inhibitory postsynaptic potential. The author has an hindex of 44, co-authored 273 publications receiving 6048 citations. Previous affiliations of Robert J. Walker include University of Düsseldorf & Hungarian Academy of Sciences.
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Journal ArticleDOI
Mapping of nerve cells in the suboesophageal ganglia of Helix aspersa.
TL;DR: The axons from some cells have been traced following intracellular injections of CoCl2 and precipitation of CoS, which supported the electrophysiological method of tracing axons by recording antidromic spikes in the cell body following stimulation of a peripheral nerve.
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A human gene encoding morphine modulating peptides related to NPFF and FMRFamide
Stephen J. Perry,Eagle Yi-Kung Huang,David Cronk,J. Bagust,Ram P. Sharma,Robert J. Walker,Shelagh Wilson,Julian F. Burke +7 more
TL;DR: It is shown that in humans 2 FMRFamide‐related peptides are encoded by a single gene expressed as a spliced mRNA, suggesting that the encoded protein is subject to cleavage by a tripeptidyl peptidase or by a novel processing mechanism.
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Anthelmintic drugs and nematicides: studies in Caenorhabditis elegans.
TL;DR: An introduction to the use of C. elegans as a 'model' parasitic nematode is provided, and approaches that have been of particular value with a view to facilitating wider-use of C.'s elegan as a platform for anthelmintic and nematicide discovery and development are highlighted.
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Cyclooctadepsipeptides--an anthelmintically active class of compounds exhibiting a novel mode of action.
Achim Harder,Hans-Peter Schmitt-Wrede,Jürgen Krücken,Predrag Marinovski,Frank Wunderlich,J. Willson,Kiran Amliwala,Lindy Holden-Dye,Robert J. Walker +8 more
TL;DR: Electrophysiological studies reveal that emodepside inhibits pharyngeal pumping of the nematodes in a concentration dependent way with an IC(50) value of about 4 nM, indicating a neuropharmacological action of these compounds.
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The action of substance P on mesencephalic reticular and substantia nigral neurones of the rat.
Robert J. Walker,Robert J. Walker,J. A. Kemp,J. A. Kemp,H. Yajima,K. Kitagawa,K. Kitagawa,Geoffrey N. Woodruff,Geoffrey N. Woodruff +8 more
TL;DR: Evidence is presented for Substance P as a putative excitatory transmitter onto reticular and nigral neurones possibly released from primary sensory afferents and in some cases this excitation was rapid.