Robert M. Hoffmann

TL;DR: The results indicate that a virus-specific CD4(+)/Th1(+) T-cell response that eliminates the virus during the acute phase of disease has to be maintained permanently to achieve long-term control of the virus.

TL;DR: The data show that the number of IFN-gamma-producing HCV-specific CD8+ T cells during the first 6 months after onset of disease is associated with eradication of the HCV infection.

TL;DR: In general, a CD4+ T lymphocyte response was more common in patients with chronic hepatitis C who responded to interferon‐alpha as compared with nonresponders, suggesting a strongCD4+ reaction before and during IFN therapy may be a predictor of sustained response.

TL;DR: In this paper, the authors reported on three patients who were treated with recombinant interferon-α2a for chronic hepatitis C, two of them in combination with ribavirin.

TL;DR: Comparison of the results obtained in proliferation assays and ELISPOT assays clearly shows that lymphokine production upon stimulation with viral protein is totally independent of T cell proliferation and more sensitively reflects antiviral reactivity.