Helmut M. Diepolder

TL;DR: NS3-specific CD4 T-cell clones from patients with self-limited infection predominantly produced interferon-gamma and may thus support cytotoxic effector mechanisms important for viral clearance.

TL;DR: The results indicate that a virus-specific CD4(+)/Th1(+) T-cell response that eliminates the virus during the acute phase of disease has to be maintained permanently to achieve long-term control of the virus.

TL;DR: IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and IEC migration, which suggests an important function in intestinal inflammation and wound healing.

TL;DR: In this article, the authors defined the natural course of acute hepatitis C virus infection and contributed to the development of treatment strategies for acute hepatitisC virus infection by using seroconversion to anti-hepatitis C virus antibodies or clinical and biochemical criteria.

TL;DR: Overall, HCV-specific CD8+T lymphocytes show reduced synthesis of tumor necrosis factor alpha and gamma interferon after stimulation with either mitogens or peptides, compared to responses to Epstein-Barr virus and/or cytomegalovirus.