scispace - formally typeset
R

Robert Malcolm

Researcher at Medical University of South Carolina

Publications -  157
Citations -  8463

Robert Malcolm is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Cocaine dependence & Alcohol dependence. The author has an hindex of 52, co-authored 155 publications receiving 7868 citations. Previous affiliations of Robert Malcolm include University of Tennessee Health Science Center & University of South Carolina.

Papers
More filters
Journal ArticleDOI

Naltrexone and Cognitive Behavioral Therapy for the Treatment of Outpatient Alcoholics: Results of a Placebo-Controlled Trial

Raymond F. Anton, +5 more
- 01 Nov 1999 - 
TL;DR: Motivated individuals with moderate alcohol dependence can be treated with greater effectiveness when naltrexone is used in conjunction with weekly outpatient cognitive behavioral therapy.
Journal ArticleDOI

Alcohol detoxification and withdrawal seizures: clinical support for a kindling hypothesis.

Martha E. Brown, +7 more
- 01 Mar 1988 - 
TL;DR: It was found that the number of detoxifications appeared to be an important variable in the predisposition to withdrawal seizures, and support the concept that previous alcohol withdrawals may "kindle" more serious subsequent withdrawal symptomatology, ultimately culminating in withdrawal seizures.
Journal ArticleDOI

The role of cystine-glutamate exchange in nicotine dependence in rats and humans.

Lori A. Knackstedt, +7 more
- 15 May 2009 - 
TL;DR: Results indicate that the cystine-glutamate exchanger and the glial glutamate transporter are downregulated after nicotine self-administration, and augmenting exchanger activity with N-acetylcysteine reduced the number of cigarettes smoked in nicotine-dependent individuals.
Journal Article

Cocaine-induced psychosis

Kathleen T. Brady, +3 more
- 01 Dec 1991 - 
TL;DR: Cocaine-induced paranoia is a common experience among chronic users and amount and duration of use are related to its development.
Journal ArticleDOI

Two CES1 gene mutations lead to dysfunctional carboxylesterase 1 activity in man: clinical significance and molecular basis.

Hao Jie Zhu, +11 more
- 06 Jun 2008 - 
TL;DR: Findings indicate that specific CES1 gene variants can lead to clinically significant alterations in pharmacokinetics and drug response of carboxylesterase 1 substrates.