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Roberto Bonasio
Researcher at University of Pennsylvania
Publications - 88
Citations - 11571
Roberto Bonasio is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Chromatin & RNA. The author has an hindex of 37, co-authored 78 publications receiving 9875 citations. Previous affiliations of Roberto Bonasio include University of Milano-Bicocca & University of Freiburg.
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Journal ArticleDOI
Dendritic cells express tight junction proteins and penetrate gut epithelial monolayers to sample bacteria.
Maria Rescigno,Matteo Urbano,Barbara Valzasina,Maura Francolini,Gianluca Rotta,Roberto Bonasio,Francesca Granucci,Jean Pierre Kraehenbuhl,Paola Ricciardi-Castagnoli +8 more
TL;DR: A new mechanism for bacterial uptake in the mucosa tissues that is mediated by dendritic cells (DCs) is reported, which open the tight junctions between epithelial cells, send dendrites outside the epithelium and directly sample bacteria.
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Molecular signals of epigenetic states.
TL;DR: A deeper understanding of epigenetic states and the mechanisms by which epigenetic information is transmitted through cell division will allow us to tackle the dysregulation of epigenetics in disease.
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PCGF homologs, CBX proteins, and RYBP define functionally distinct PRC1 family complexes.
Zhonghua Gao,Jin Zhang,Roberto Bonasio,Francesco Strino,Ayana Sawai,Fabio Parisi,Yuval Kluger,Danny Reinberg +7 more
TL;DR: A comprehensive proteomic and genomic analysis uncovered six major groups of PRC1 complexes, each containing a distinct PCGF subunit, a RING1A/B ubiquitin ligase, and a unique set of associated polypeptides.
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SAVER: gene expression recovery for single-cell RNA sequencing.
Mo Huang,Jingshu Wang,Eduardo A. Torre,Hannah Dueck,Sydney M. Shaffer,Roberto Bonasio,John I. Murray,Arjun Raj,Mingyao Li,Nan Zhang +9 more
TL;DR: SAVER (single-cell analysis via expression recovery), an expression recovery method for unique molecule index (UMI)-based scRNA-seq data that borrows information across genes and cells to provide accurate expression estimates for all genes.
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Genomic Comparison of the Ants Camponotus floridanus and Harpegnathos saltator
Roberto Bonasio,Guojie Zhang,Guojie Zhang,Chaoyang Ye,Navdeep S. Mutti,Xiaodong Fang,Nan Qin,Greg Donahue,Pengcheng Yang,Qiye Li,Cai Li,Pei Zhang,Zhiyong Huang,Shelley L. Berger,Danny Reinberg,Jun Wang,Jun Wang,Juergen Liebig +17 more
TL;DR: The genomes of two socially divergent ant species exhibiting differences in caste development are sequenced and used to compare gene expression and identify differences in epigenetic gene regulation that lead to the phenotypic differences.