Roberto Scandurra

TL;DR: The structure determination of glutamate dehydrogenase from P. furiosus contains a striking series of ion-pair networks on the surface of the protein subunits and buried at both interdomain and intersubunit interfaces, which suggest that the formation of such extended networks may represent a major stabilizing feature associated with the adaptation of enzymes to extreme temperatures.

TL;DR: Results indicate that Cd increases BC cell proliferation in vitro by stimulating Akt, ERK1/2 and PDGFRalpha kinases activity likely by activating c-fos, c-jun andPDGFA by an ERalpha-dependent mechanism.

TL;DR: Data show that raloxifene negatively modulates osteoclasts, and positively affects osteoblasts, suggesting not only an antiresorptive role, but also an osteoblast stimulatory role.

TL;DR: From the comparative analysis of the X-ray structures available for several families of proteins, including at least one thermophilic structure in each case, it appears that thermal stabilization is accompanied by an increase in hydrogen bonds and salt bridges.

TL;DR: It is concluded that coating with TiC will, in comparison to uncoated titanium, improve implant hardness, biocompatibility through surface stability and osseointegration through improved bone growth.