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Robin Antrobus
Researcher at University of Cambridge
Publications - 89
Citations - 4125
Robin Antrobus is an academic researcher from University of Cambridge. The author has contributed to research in topics: Innate immune system & Human cytomegalovirus. The author has an hindex of 35, co-authored 83 publications receiving 3157 citations.
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Journal ArticleDOI
The exocyst complex is an essential component of the mammalian constitutive secretory pathway
Conceição Pereira,Daniel Stalder,Georgina Anderson,Amber S. M. Shun-Shion,Jack W. Houghton,Robin Antrobus,Michael A Chapman,Daniel J. Fazakerley,David C. Gershlick +8 more
TL;DR: The knock-out of exocyst subunits in specialised secretory cell types prevents the constitutive secretion of antibodies in lymphocytes and of the hormones leptin and adiponectin in adipocytes, and these data identify theExocyst complex as the functional tether of secretory post-Golgi carriers at the plasma membrane and an essential component of the mammalian constitutive secretory pathway.
Posted ContentDOI
Phosphorylation of MX2 regulates innate immunity against HIV-1
Gilberto Betancor,Jose M. Jimenez-Guardeño,Steven Lynham,Robin Antrobus,Hataf Khan,Andrew Sobala,Matthew D. J. Dicks,Michael H. Malim +7 more
TL;DR: It is proposed that homeostatic repression of MX2 through NTD phosphorylation, together with its reversal by MLCP and IFN, balances the deleterious effects ofMX2 on normal cell function with innate immunity against HIV-1.
Journal ArticleDOI
Proteomic analysis of circulating immune cells identifies cellular phenotypes associated with COVID-19 severity
Martin Potts,Alice Fletcher-Etherington,Katie Nightingale,Federica Mescia,Laura Bergamaschi,Fernando J Calero-Nieto,Robin Antrobus,James Williams,Edward L. Huttlin,Nathalie Kingston,Berthold Göttgens,John S. Bradley,Paul J. Lehner,Nicholas J Matheson,Kenneth G. C. Smith,Mark R. Wills,Paul A. Lyons,Michael P. Weekes +17 more
TL;DR: In this article , the authors performed an unbiased analysis of total and plasma-membrane PBMC proteomes from 40 unvaccinated individuals with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), spanning the whole disease spectrum.
Posted ContentDOI
Non-canonical circadian oscillations in Drosophila S2 cells drive gene-expression cycles coupled to metabolic oscillations
Guillaume Rey,Nikolay B. Milev,Utham K. Valekunja,Ratnasekhar Ch,Sandipan Ray,Mariana Silva dos Santos,András D. Nagy,Robin Antrobus,James I. MacRae,Akhilesh B. Reddy +9 more
TL;DR: It is demonstrated that daily genome-wide oscillations, coupled to metabolic cycles, take place in eukaryotic cells without the contribution of known circadian regulators.