R
Robin Antrobus
Researcher at University of Cambridge
Publications - 89
Citations - 4125
Robin Antrobus is an academic researcher from University of Cambridge. The author has contributed to research in topics: Innate immune system & Human cytomegalovirus. The author has an hindex of 35, co-authored 83 publications receiving 3157 citations.
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Control of immune ligands by members of a cytomegalovirus gene expansion suppresses natural killer cell activation
Ceri Alan Fielding,Michael P. Weekes,Luis Nobre,Eva Ruckova,Gavin S. Wilkie,Joao A. Paulo,Chiwen Chang,Nicolás M. Suárez,James A. Davies,Robin Antrobus,Richard J. Stanton,Rebecca Aicheler,Hester Nichols,Borek Vojtesek,John Trowsdale,Andrew J. Davison,Steven P. Gygi,Peter Tomasec,Paul J. Lehner,Gavin W. G. Wilkinson +19 more
TL;DR: It is demonstrated that the US12 family selectively targets plasma membrane proteins and plays key roles in regulating NK ligands, adhesion molecules and cytokine receptors and is identified as a major new hub of immune regulation.
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A Spaetzle-like role for nerve growth factor β in vertebrate immunity to Staphylococcus aureus
Lucy Hepburn,Tomasz K. Prajsnar,Catherine Klapholz,Pablo Moreno,Catherine A. Loynes,Nikolay V. Ogryzko,Karen Brown,Karen Brown,Mark Schiebler,Krisztina Hegyi,Robin Antrobus,Katherine L. Hammond,John E. Connolly,Bernardo Montano Ochoa,Clare E. Bryant,Michael Otto,Bas G.J. Surewaard,Suranjith L. Seneviratne,Dorothy M Grogono,Dorothy M Grogono,Julien Cachat,Tor Ny,Arthur Kaser,M. Estée Török,Sharon J. Peacock,Sharon J. Peacock,Matthew T. G. Holden,Matthew T. G. Holden,Tom L. Blundell,Lihui Wang,Petros Ligoxygakis,Liliana Minichiello,C. Geoff Woods,Simon J. Foster,Stephen A. Renshaw,R. Andres Floto,R. Andres Floto +36 more
TL;DR: The structurally related cystine-knot protein, nerve growth factor β (NGFβ), plays an unexpected Spaetzle-like role in immunity to Staphylococcus aureus infection in chordates.
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Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens
Richard T. Timms,Sam A. Menzies,Iva A. Tchasovnikarova,Lea Cecilie Christensen,James C Williamson,Robin Antrobus,Gordon Dougan,Lars Ellgaard,Paul J. Lehner +8 more
TL;DR: This head-to-head comparison aimed to identify genes required for the endoplasmic reticulum-associated degradation (ERAD) of MHC class I molecules shows high concordance, successfully identifying the majority of the known components of the canonical glycoprotein ERAD pathway.
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Fat mass and obesity-related (FTO) shuttles between the nucleus and cytoplasm
Pawan Gulati,Edward Avezov,Marcella Ma,Robin Antrobus,Paul J. Lehner,Stephen O'Rahilly,Giles S.H. Yeo +6 more
TL;DR: Live cell imaging of GFP (green fluorescent protein)-FTO is undertaken, and it is demonstrated that FTO resides in both the nucleus and cytoplasm, with a mobile fraction that shuttles between both cellular compartments.
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MHC class I molecules are preferentially ubiquitinated on endoplasmic reticulum luminal residues during HRD1 ubiquitin E3 ligase-mediated dislocation
Marian L. Burr,Dick J. H. van den Boomen,Helen Bye,Robin Antrobus,Emmanuel J. H. J. Wiertz,Paul J. Lehner +5 more
TL;DR: The requirements for MHC I ubiquitination and degradation are investigated and it is shown that endogenous misfolded M HC I HCs are recognized in the ER lumen by EDEM1 in a glycan-dependent manner and targeted to the core SEL1L/HRD1/UBE2J1 complex.