R
Rodrigo Ledesma-Amaro
Researcher at Imperial College London
Publications - 158
Citations - 4556
Rodrigo Ledesma-Amaro is an academic researcher from Imperial College London. The author has contributed to research in topics: Medicine & Yarrowia. The author has an hindex of 30, co-authored 101 publications receiving 2594 citations. Previous affiliations of Rodrigo Ledesma-Amaro include Université Paris-Saclay & University of Salamanca.
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Synthetic Biology Tools to Engineer Microbial Communities for Biotechnology
TL;DR: Recent advancements in synthetic biology tools and approaches to engineer synthetic microbial Consortia are reviewed, ongoing and emerging efforts to apply consortia for various biotechnological applications are discussed, and future applications are suggested.
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Multiplexed CRISPR technologies for gene editing and transcriptional regulation.
TL;DR: This review discusses multiplexed CRISPR technologies and describes methods for the assembly, expression and processing of synthetic guide RNA arrays in vivo, and offers a glimpse of emerging challenges and emphasize experimental considerations for future studies.
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Yarrowia lipolytica as a biotechnological chassis to produce usual and unusual fatty acids
TL;DR: The variety of lipids produced by oleaginous microorganisms is expected to rise in the coming years to cope with the increasing demand.
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A synthetic biology approach to transform Yarrowia lipolytica into a competitive biotechnological producer of β-carotene
Macarena Larroude,Ewelina Celińska,Alexandre Back,Stephan Thomas,Jean-Marc Nicaud,Rodrigo Ledesma-Amaro +5 more
TL;DR: High titers suggest that engineered Y. lipolytica is a competitive producer organism of β‐carotene, and develops a combinatorial synthetic biology approach base on Golden Gate DNA assembly to screen the optimum promoter‐gene pairs for each transcriptional unit expressed.
Journal ArticleDOI
Metabolic engineering of Yarrowia lipolytica to produce chemicals and fuels from xylose.
Rodrigo Ledesma-Amaro,Zbigniew Lazar,Magdalena Rakicka,Zhongpeng Guo,Florian Fouchard,Anne-Marie Crutz-Le Coq,Jean-Marc Nicaud +6 more
TL;DR: This mutant was able to produce up to 80g/L of citric acid from xylose and is the first step towards a consolidated bioprocess to produce chemicals and fuels from lignocellulosic materials.