Roel P.F. Schins

TL;DR: There is now an opportunity to apply knowledge from NM toxicology and use it to better inform PM health risk research and vice versa.

TL;DR: This review focuses on the cellular actions and interactions of key inflammatory cells and target cells in coal dust toxicity and related lung disorders, i.e.macrophages and neutrophils, epithelial cells, and fibroblasts, and components of the extracellular matrix (ECM), including the modifying role of ROS, cytokines, proteases and antiproteases are discussed in relation to tissue damage and remodelling in the respiratory tract.

TL;DR: N nanoparticles and reactive oxidative species induce DNA damage, activating p53 and proteins related to DNA repair, mimicking irradiation-related carcinogenesis pathways.

TL;DR: The results show that ZnO, DQ12 quartz and amorphous silica are cytotoxic with strong indications for apoptotic effects in RAW 264.7 macrophages, whereas toxicity was absent for MgO.

TL;DR: In conclusion, NPCB and BaP-NPCB induce DNA damage, activating p53, proteins related to DNA repair and proinflammatory transcription factors, and N-acetylcysteine blocked NP driven effects.