R
Roeland J.W. Middelbeek
Researcher at Harvard University
Publications - 46
Citations - 2173
Roeland J.W. Middelbeek is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 11, co-authored 28 publications receiving 1628 citations. Previous affiliations of Roeland J.W. Middelbeek include Beth Israel Deaconess Medical Center & Brigham and Women's Hospital.
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Journal ArticleDOI
Brown adipose tissue regulates glucose homeostasis and insulin sensitivity
Kristin I. Stanford,Roeland J.W. Middelbeek,Kristy L. Townsend,Ding An,Eva B. Nygaard,Kristen M. Hitchcox,Kathleen R. Markan,Kazuhiro Nakano,Michael F. Hirshman,Yu-Hua Tseng,Laurie J. Goodyear +10 more
TL;DR: A previously under-appreciated role for BAT in glucose metabolism is revealed, demonstrating that BAT-derived IL-6 is required for the profound effects of BAT transplantation on glucose homeostasis and insulin sensitivity.
Journal ArticleDOI
Exercise Effects on White Adipose Tissue: Beiging and Metabolic Adaptations
TL;DR: Recent studies that have investigated the effects of exercise training on mitochondrial function, the “beiging” of WAT, regulation of adipokines, metabolic effects of trained adipose tissue on systemic metabolism, and depot-specific responses to exercise training are discussed.
Journal ArticleDOI
A Novel Role for Subcutaneous Adipose Tissue in Exercise-Induced Improvements in Glucose Homeostasis
Kristin I. Stanford,Roeland J.W. Middelbeek,Roeland J.W. Middelbeek,Kristy L. Townsend,Kristy L. Townsend,Min-Young Lee,Min-Young Lee,Hirokazu Takahashi,Hirokazu Takahashi,Kawai So,Kristen M. Hitchcox,Kathleen R. Markan,Katharina Hellbach,Michael F. Hirshman,Yu-Hua Tseng,Yu-Hua Tseng,Laurie J. Goodyear,Laurie J. Goodyear +17 more
TL;DR: Exercise training causes adaptations to scWAT that elicit metabolic improvements in other tissues, demonstrating a previously unrecognized role for adipose tissue in the beneficial effects of exercise on systemic glucose homeostasis.
Journal ArticleDOI
12,13-diHOME: An Exercise-Induced Lipokine that Increases Skeletal Muscle Fatty Acid Uptake
Kristin I. Stanford,Matthew D. Lynes,Hirokazu Takahashi,Lisa A. Baer,Peter J. Arts,Francis J. May,Adam C. Lehnig,Roeland J.W. Middelbeek,Jeffrey J. Richard,Kawai So,Emily Y. Chen,Fei Gao,Niven R. Narain,Giovanna Distefano,Vikram Shettigar,Michael F. Hirshman,Mark T. Ziolo,Michael A. Kiebish,Yu-Hua Tseng,Paul M. Coen,Laurie J. Goodyear +20 more
TL;DR: Analysis of lipidomics analysis revealed that a bout of moderate-intensity exercise causes a pronounced increase in the circulating lipid 12,13-dihydroxy-9Z-octadecenoic acid (12, 13-diHOME) in male, female, young, old, sedentary, and active human subjects.
Journal ArticleDOI
TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism
Hirokazu Takahashi,Christiano R. R. Alves,Kristin I. Stanford,Kristin I. Stanford,Roeland J.W. Middelbeek,Pasquale Nigro,Rebecca E. Ryan,Ruidan Xue,Masaji Sakaguchi,Matthew D. Lynes,Kawai So,Joram D. Mul,Min-Young Lee,Estelle Balan,Hui Pan,Jonathan M. Dreyfuss,Michael F. Hirshman,Mohamad Azhar,Jarna C. Hannukainen,Pirjo Nuutila,Kari K. Kalliokoski,Søren Nielsen,Bente Klarlund Pedersen,C. Ronald Kahn,Yu-Hua Tseng,Laurie J. Goodyear +25 more
TL;DR: It is shown that transforming growth factor-β2 is secreted from adipose tissue in response to exercise and improves glucose tolerance in mice, and exercise training improves systemic metabolism through inter-organ communication with fat via a lactate–TGF- β2 signaling cycle.