W
Wade S. Samowitz
Researcher at University of Utah
Publications - 194
Citations - 18254
Wade S. Samowitz is an academic researcher from University of Utah. The author has contributed to research in topics: Colorectal cancer & Population. The author has an hindex of 63, co-authored 193 publications receiving 17380 citations. Previous affiliations of Wade S. Samowitz include University of California, Irvine & University of Texas Southwestern Medical Center.
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Journal ArticleDOI
Identification and characterization of the familial adenomatous polyposis coli gene
Joanna Groden,Andrew Thliveris,Andrew Thliveris,Wade S. Samowitz,M. Carlson,Lawrence Gelbert,Lawrence Gelbert,Hans Albertsen,Geoff Joslyn,Geoff Joslyn,Jeff Stevens,Jeff Stevens,Lisa Spirio,Margaret Robertson,Margaret Robertson,Leslie Sargeant,Leslie Sargeant,Karen Krapcho,Karen Krapcho,E. Wolff,E. Wolff,Randall W. Burt,John P. Hughes,Janet A. Warrington,John Douglas Mcpherson,John J. Wasmuth,Denis Le Paslier,Hadi Abderrahim,Daniel Cohen,Mark Leppert,Mark Leppert,Ray White,Ray White +32 more
TL;DR: DNA from 61 unrelated patients with adenomatous polyposis coli (APC) was examined for mutations in three genes located within a 100 kb region deleted in two of the patients, and data have established that DP2.5 is the APC gene.
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Identification of deletion mutations and three new genes at the familial polyposis locus
Geoff Joslyn,Geoff Joslyn,M. Carlson,Andrew Thliveris,Andrew Thliveris,Hans Albertsen,Lawrence Gelbert,Lawrence Gelbert,Wade S. Samowitz,Joanna Groden,Jeff Stevens,Jeff Stevens,Lisa Spirio,Margaret Robertson,Margaret Robertson,Leslie Sargeant,Leslie Sargeant,Karen Krapcho,Karen Krapcho,E. Wolff,E. Wolff,Randall W. Burt,John P. Hughes,Janet A. Warrington,John Douglas Mcpherson,John J. Wasmuth,Denis Le Paslier,Hadi Abderrahim,Daniel Cohen,Mark Leppert,Mark Leppert,Ray White,Ray White +32 more
TL;DR: Small (100-260 kb), nested deletions were characterized in DNA from two unrelated patients with familial adenomatous polyposis coli (APC) and two new genes contained sequence identical to SRP19, the gene coding for the 19 kd component of the ribosomal signal recognition particle.
Journal ArticleDOI
Poor Survival Associated with the BRAF V600E Mutation in Microsatellite-Stable Colon Cancers
Wade S. Samowitz,Carol Sweeney,Jennifer S. Herrick,Hans Albertsen,Theodore R. Levin,Maureen A. Murtaugh,Roger K. Wolff,Martha L. Slattery +7 more
TL;DR: It is concluded that the BRAF V600E mutation in microsatellite-stable colon cancer is associated with a significantly poorer survival in stages 2 to 4 colon cancer but has no effect on the excellent prognosis of micros satellite-unstable tumors.
Journal ArticleDOI
Alleles of the APC gene: An attenuated form of familial polyposis
Lisa Spirio,Sylviane Olschwang,Joanna Groden,Margaret Robertson,Wade S. Samowitz,Geoff Joslyn,Lawrence Gelbert,Andrew Thliveris,M. Carlson,Brith Otterud,Henry T. Lynch,Patrice Watson,Patrick M. Lynch,Pierre Laurent-Puig,Randall W. Burt,John P. Hughes,Gilles Thomas,Mark Leppert,Ray White +18 more
TL;DR: Four distinct mutations in the APC gene have now been identified in seven AAPC families, and they differ in that the four mutated sites are located very close to one another and nearer the 5' end of theAPC gene than any base substitutions or small deletions yet discovered in patients with classical APC.
Journal ArticleDOI
Evaluation of a Large, Population-Based Sample Supports a CpG Island Methylator Phenotype in Colon Cancer
Wade S. Samowitz,Hans Albertsen,Jennifer S. Herrick,Theodore R. Levin,Carol Sweeney,Maureen A. Murtaugh,Roger K. Wolff,Martha L. Slattery +7 more
TL;DR: The evaluation of a large, population-based sample of individuals with colon cancer strongly supports the biologic relevance of CIMP in colon cancer, however, the presence or absence of microsatellite instability has a major effect on the expression of this phenotype.