Thomas A. Weston

TL;DR: Respirometry reveals that the constituents of these newly established mitochondrial networks are better primed for OXPHOS and are more tightly coupled than those in myoblasts, which highlights the integral role of autophagy and mitophagy in myogenic differentiation.

TL;DR: In vitro studies used to demonstrate the rapid and directional transcytosis of diverse bacteriophages across confluent cell layers originating from the gut, lung, liver, kidney, and brain reveal that phages interact directly with the cells and organs of the authors' bodies, likely contributing to human health and immunity.

TL;DR: It is determined that BspC interacts with the host cytoskeleton component vimentin and this interaction is critical for the pathogenesis of GBS meningitis, and Vimentin null mice were protected from WT GBS infection and also exhibited less inflammatory cytokine production in brain tissue.

TL;DR: This study has further characterized the interaction of GBS with human astrocytes, and has identified the importance of specific virulence factors in these interactions.

TL;DR: RNA sequencing revealed global transcriptional differences between the ΔltdR mutant and the parental wild-type GBS strain and suggested that LtdR regulates many bacterial processes that can influence GBS-host interactions to promote both bacterial persistence and disease progression.