Bethan L. Clifford

TL;DR: The authors showed that FXR activation in mice or humans specifically reduces hepatic levels of mono-and polyunsaturated fatty acids (MUFA and PUFA) and selective decreases in fatty acid synthesis.

TL;DR: This study interrogated lipid regulatory networks in 107 genetically distinct mouse strains to reveal key insights into the control and network structure of mammalian lipid metabolism, leading to the identification and validation of PSMD9 as a previously unknown lipid regulatory protein.

TL;DR: The ZFP36L1-dependent regulation of bile acid metabolism is an important metabolic contributor to obesity and hepatosteatosis and it is found that mice lacking hepatic ZFP 36L1 were protected from diet-induced obesity and steatosis.

TL;DR: The data demonstrate silencing miR-144 has sex-specific effects and that treatment with antisense oligonucleotides to target mi R-144 might result in enhancements in reverse cholesterol transport and oxysterol metabolism in patients with cardiovascular disease.